Life Science Alliance - New York Press Releases - EIN Presswire

Published on June 21, 2024 - 18:09 GMT

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/...

Introduction Amyotrophic lateral sclerosis (ALS) is characterised by the loss of upper and lower motor neurons leading to symptoms such as muscle weakness and paralysis. A plethora of evidence supports a clinical, pathologic, and genetic overlap between …

Distribution channels:

Published on June 21, 2024 - 18:09 GMT

Recent approaches in computational modelling for controlling pathogen threats

Computational infectious disease modelling is the attempt to approximate the real-world biological processes of pathogen transmission, control, and evolution using mathematical and/or simulation-based techniques. In this review, we provide an overview of …

Distribution channels:

Published on June 21, 2024 - 18:09 GMT

The type of DNA damage response after decitabine treatment depends on the level of DNMT activity

Introduction 5-Aza-2′-deoxycytidine (decitabine, AzadC) and 5-azacytidine (Azacytidine, AzaC) are cytosine analogues that covalently trap DNA methyltransferases (DNMTs) and therefore belong to the compound class of hypomethylating agents (HMAs) (1, 2). …

Distribution channels:

Published on June 17, 2024 - 18:18 GMT

C. elegans LIN-66 mediates EIF-3/eIF3-dependent protein translation via a cold-shock domain

Introduction Protein translation initiation in eukaryotic cells is highly regulated and involves coordinated actions of multiple protein complexes, known as eIF1-6 (Hinnebusch & Lorsch, 2012). The eIF complexes work in concert to orchestrate orderly …

Distribution channels:

Published on June 17, 2024 - 18:18 GMT

Congress of multiple dimers is needed for cross-phosphorylation of IRE1{alpha} and its RNase activity

Introduction Reliability of signal transduction is crucial for cell function and survival. The vast majority of secretory proteins fold and assemble in the endoplasmic reticulum (ER) under the assistance of resident chaperones and enzymes. Folding …

Distribution channels:

Published on June 14, 2024 - 22:26 GMT

Single-housing-induced islet epigenomic changes are related to polymorphisms in diabetic KK mice

Introduction Type 2 diabetes (T2D) is a continual clinical concern with an enormous impact on public health and is socioeconomically important (Ogurtsova et al, 2017). Many studies have shown the involvement of both genetic predispositions and …

Distribution channels:

Published on June 14, 2024 - 22:26 GMT

Correction: Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

Correction: Transcription dynamics during severe dengue fever Priyanka Mehta, Chinky Shiu Chen Liu, Sristi Sinha, Ramakant Mohite, Smriti Arora, Partha Chattopadhyay, Sandeep Budhiraja, Bansidhar Tarai, Rajesh Pandey Life Science Alliance Jun 2024, 7 (9) …

Distribution channels:

Published on June 14, 2024 - 22:26 GMT

Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm

Introduction Motile cilia/flagella are antenna-like organelles protruding from the cell surface and have been conserved among eukaryotes (Satir & Christensen, 2007). They show various types of beating optimized for their functions, such as the …

Distribution channels:

Published on June 14, 2024 - 22:26 GMT

The transcription factor HIF-1{alpha} in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis

Innate lymphoid cells (ILCs) are critical for intestinal adaptation to microenvironmental challenges, and the gut mucosa is characterized by low oxygen. Adaptation to low oxygen is mediated by hypoxia-inducible transcription factors (HIFs), and the HIF-1α …

Distribution channels:

Published on June 13, 2024 - 05:14 GMT

Exploring the molecular composition of the multipass translocon in its native membrane environment

Introduction The ribosome-associated endoplasmic reticulum (ER) translocon complex facilitates the biogenesis of most secretory and membrane proteins (Gemmer & Forster, 2020). The ribosome binds to the protein-conducting channel Sec61, a heterotrimeric …

Distribution channels:

Published on June 10, 2024 - 21:27 GMT

The nucleolar phase of signal recognition particle assembly

Introduction The eukaryotic rough ER coordinates the biogenesis, folding, post-translational modifications, and sorting of membrane-associated and secreted proteins. Protein secretion is crucial to maintaining cell compartmentalization and homeostasis. In …

Distribution channels:

Published on June 6, 2024 - 18:57 GMT

Nono induces Gadd45b to mediate DNA repair

Introduction The DNA damage response (DDR) repairs DNA double-strand breaks (DSBs), which are toxic and threaten genome stability (Jackson & Bartek, 2009; Ciccia & Elledge, 2010). The recognition of DSBs is governed by kinases such as ataxia– …

Distribution channels:

Published on June 6, 2024 - 18:57 GMT

Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity

Introduction Cells invest substantial resources to generate an enormous repertoire of lipid species with diverse physico-chemical and structural properties. Lipid species composition is organ-specific, cell type–specific and even conserved at the sub- …

Distribution channels:

Published on June 6, 2024 - 18:57 GMT

STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells

Introduction The regenerative potential of skeletal muscle relies on the presence of muscle stem cells (MuSCs) located underneath the basal lamina in a quiescent state (Evano & Tajbakhsh, 2018). In response to stress or injury, MuSCs exit the …

Distribution channels:

Published on June 5, 2024 - 18:58 GMT

Off-targets of BRAF inhibitors disrupt endothelial signaling and vascular barrier function

Introduction Melanoma is a highly aggressive form of skin cancer and is associated with a high mortality rate (Schadendorf et al, 2018). According to previous literature, ∼50% of melanomas harbor mutations in the BRAF gene, of which the vast majority …

Distribution channels:

Published on June 4, 2024 - 18:17 GMT

IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesion

Introduction Vinculin is a cytoskeletal linker of integrin-mediated matrix adhesions and cadherin-based cell-cell junctions (Goldman, 2016; Bays & DeMali, 2017). It plays an important role in cell adhesion processes, motility and development and its …

Distribution channels:

Published on June 4, 2024 - 00:18 GMT

Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression

Introduction Mast cells are tissue-resident immune cells that exert key effector functions during allergic and anaphylactic reactions, act as sentinels against invading pathogens, and regulate physiological processes, such as tissue repair and angiogenesis …

Distribution channels:

Published on June 4, 2024 - 00:18 GMT

Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing

Introduction Dengue, a pervasive vector-borne viral disease, annually afflicts around 400 million individuals and claims the lives of 40,000 people worldwide (1). Despite witnessing a substantial increase in dengue cases over the past decade, it remains …

Distribution channels:

Published on June 4, 2024 - 00:18 GMT

Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity

Introduction Lymphocyte development initiates in utero and continues after birth in the bone marrow and thymus (Montecino-Rodriguez & Dorshkind, 2012; Kobayashi & Yoshimoto, 2023), but lymphopoiesis is not a linear process. Instead, hematopoietic …

Distribution channels:

Published on June 4, 2024 - 00:18 GMT

Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins

Introduction The genesis of the umbilical cord helices remains an elusive phenomenon in fetal development. The human umbilical cord (hUC) supplies nutrients and oxygen to the fetus and is indispensable for the adequate development of the fetus. The hUC …

Distribution channels: