Introduction Lymphocyte development initiates in utero and continues after birth in the bone marrow and thymus (Montecino-Rodriguez & Dorshkind, 2012; Kobayashi & Yoshimoto, 2023), but lymphopoiesis is not a linear process. Instead, hematopoietic …
Introduction Mitochondrial morphology is controlled by the balance between two opposing processes, fusion and fission. These highly regulated events adapt the cellular mitochondrial network to the bioenergetic requirements of the cell and maintain the …
Introduction Horizontal gene transfer is an important way for bacteria to spread genetic information between populations, for example, for the propagation of antibiotic resistance or virulence genes (Von Wintersdorff et al, 2016). Conjugation is one type …
Differential growth corrects errors in size partitioning To study the control of asymmetric size partitioning in C. crescentus cells, we first analyzed cell growth dynamics during the division cycle with various size discrepancies between the stalked and …
Introduction The structural and functional reorganization during cell differentiation is a metabolically demanding process. Many proteins and other macromolecules are replaced, and the cytoskeleton is reorganized leading to changes in the cell’s shape and …
Introduction Colorectal cancer (CRC) is the third most occurring cancer and the second leading cause of cancer-related mortality worldwide (1). The course of the disease is impacted by vast heterogeneity across patients, as oncogenic mutations occur in …
Introduction The super-family of seven-transmembrane (7TM) receptors, of which most are G protein–coupled receptors (GPCRs), are critical mediators of numerous physiological and pathological processes in the human body. Accordingly, GPCRs are the largest …
Introduction The ER is the largest membrane-bound organelle and is involved in essential functions, including protein and lipid biosynthesis and calcium homeostasis. Similar to other cellular membranes, the ER lipid bilayer is organized in protein and …
Case Presentation A 12-yr-old male with autism presented to our institution after cardiac arrest; he was otherwise previously healthy with no familial cardiac history, on vacation. Per the history provided by the mother and bystanders, the patient was …
Introduction REH, established in 1974 as the first B-cell precursor acute lymphoblastic leukemia (ALL) cell line, was derived from the peripheral blood of a 15-yr-old female patient at relapse (Rosenfeld et al, 1977). REH has a near-diploid karyotype …
Introduction Ubiquitination is a post-translational modification, which regulates almost every cellular process. To achieve this, a ubiquitin (Ub) signal is added onto the substrate protein, recruiting specific ubiquitin-binding proteins (UbBPs) via their …
Introduction IGHMBP2 is a ubiquitously expressed, superfamily 1 (SF1) DNA/RNA helicase implicated in the regulation of mRNA translation (Grohmann et al, 2001; de Planell-Saguer et al, 2009). IGHMBP2 loss-of-function mutations cause the rare autosomal …
Result p53 is up-regulated in FKBP52-KD cells We found that depletion of FKBP52 in MCF7 breast cancer cells expressing WT p53 markedly inhibited proliferation (Habara et al, 2022). To elucidate this mechanism, we performed RNA-seq analysis and GSEA in …
Introduction The regulation of translation initiation shapes cellular proteomes in organisms ranging from bacteria to humans. In eukaryotes, translation preinitiation complexes typically scan unidirectionally from the 5′ end of mRNAs and initiate …
Introduction Tuberculosis (TB) is among the principal causes of death because of infectious diseases in the world. This situation was worsened by the recent burden imposed on healthcare systems by the COVID-19 crisis, which severely affected TB management …
2Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA 6Department of Chemistry, College of Arts and Sciences, University of South Florida, Tampa, FL, USA 7Global and Planetary Health, College of Public …
Introduction Homologous recombination (HR) is a DNA repair process found in all forms of life that is pivotal for maintaining genomic integrity and ensuring genetic diversity (Ranjha et al, 2018; Wright et al, 2018). In somatic cells, HR is used to repair …
The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the invasive merozoite stages of Plasmodium falciparum and has long been considered a key target of protective immunity. We used samples from a single controlled human …
Introduction Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, with an estimate of 17,000 patients and ∼5,000 new cases annually only in Europe (Marin et al, 2017). Worldwide incidence is ∼1.6 cases per 100,000 persons annually ( …
Introduction By far, the largest fraction of cancer-related deaths occurs through metastasis, and thus, metastasis is the greatest challenge to cancer therapy. Although new approaches have been established, such as immune checkpoint or cell-based therapies …
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