Introduction After the fusion of the oocyte and sperm, the zygote undergoes a series of cell divisions until it forms a blastocyst before implantation into the uterus. A human blastocyst is formed of a fluid-filled cavity and ∼200 cells that comprise three …
Correction: 1,6-HD treatment perturbs polycomb chromatin foci Iain Williamson, Shelagh Boyle, Graeme R Grimes, Elias T Friman, Wendy A Bickmore Life Science Alliance Oct 2023, 7 (1) e202302436; DOI: 10.26508/lsa.202302436
Introduction The primary cilium is a cellular organelle that projects from the surface of most cell types. It performs sensory, mechanical, and signal processing functions, and regulates numerous critical developmental processes, including neurogenesis, …
Introduction Cancer cells are characterized by unrestrained proliferation and dysregulated growth, which lead to the formation of malignant neoplasms (Hanahan & Weinberg, 2023). The development and progression of cancer have been linked to the …
Introduction Trafficking of proteins, lipids, and other molecules between cellular compartments is carried out by vesicular carriers. Material destined for transfer is packaged into a small trafficking vesicle at the donor compartment; the vesicle must …
Introduction Soft-tissue sarcomas (STSs) are heterogeneous subtypes of tumors with distinct origins and genomic profiles (Fletcher, 2014). To stratify them and define prognostic markers, large-scale approaches have revealed how histio- and genotypes are …
Introduction Immunogenicity is a term used in the pharmaceutical industry to describe the undesired immune responses to therapeutic proteins (Bhogal, 2010). It has been over three decades since the United States Food and Drug Administration (US FDA) …
Introduction Calcium ions (Ca2+) act as important second messengers in all cells, regulating vital aspects of cellular function from cell proliferation to cell death (Schwarz & Blower, 2016; Giorgi et al, 2018). In the nervous system, Ca2+ signaling …
Introduction Ras belongs to a family of small G protein that switches between two states, GDP-bound form (RasGDP) and GTP-bound form (RasGTP), and regulates a wide range of cellular activities (Cox & Der, 2010). Guanine nucleotide exchange factors ( …
SBDSR126T rescued the sbds−/− zebrafish We recently reported that sbds-null fish died between 15–21 dpf. We generated a zebrafish transgenic line expressing the zebrafish WT sbds under the zebrafish ubiquitin (ubi) promoter: Tg(ubi:sbds:pA), which drives …
Introduction Lung cancer is the second most commonly diagnosed cancer worldwide and the leading cause of cancer death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all lung cancers (1, 2). Targeted drugs represented by epidermal growth factor …
Introduction The skeletal muscle is composed of elongated syncytia (or myofibers) that are formed by the fusion of hundreds of mononucleated myoblasts during embryonic development. The skeletal muscle has a remarkable capability to regenerate, which is …
Introduction A complete genome assembly is required to understand the unique aspects of tick biology and to develop control strategies to reduce their capacity to spread a wide variety of pathogens. The Ixodes scapularis genome is relatively large among …
Introduction Because it is the most aggressive and chemotherapy-resistant of all human malignancies, pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis. Most PDAC patients survive only 3–6 mo after the first diagnosis, which usually occurs too …
Referring to the following published article: Article: Suen KM, Sheard TMD, Lin C-C, Milonaityte D, Jayasinghe I, Ladbury JE (2023 Feb 7) Expansion microscopy reveals subdomains in C. elegans germ granules. Life Sci Alliance 6(4): e202201650. doi: 10.26508 …
Abstract At the core of cilia are microtubules which establish length and assist ciliary assembly and disassembly; however, microtubules outside of the cilium can regulate ciliogenesis. The microtubule cytoskeleton polymerizes and depolymerizes rapidly. …
Introduction DYRK1A (dual-specificity tyrosine-phosphorylation regulated kinase 1A) is a proline-directed serine/threonine protein kinase belonging to the CMGC family (Becker & Joost, 1999). The amino acid sequence of the catalytic domain of DYRK1A is …
Introduction Progenitor populations in the developing cortex During the early phases of neocortical development, proliferative neuroepithelial cells (NECs) undergo amplifying symmetric divisions to contribute to the tangential expansion of the neocortex ( …
Introduction Chronic inflammation is a hallmark of HIV-1 infection, and it persists even when combination antiretroviral therapy is effective (Deeks et al, 2013). This persistent inflammation is now widely recognized as a major risk factor for the severity …
Introduction Accurate segregation of duplicated genetic material requires dynamic and regulated attachment of the sister chromatids to spindle microtubules (MTs). This association is mediated by the kinetochore, a multiprotein complex that assembles on the …
