E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors
Introduction The closely related transmembrane E3 ligases RNF43 and ZNRF3 control cell surface abundance of Frizzled (FZD) proteins, the primary receptors for WNT, by promoting their ubiquitination and lysosomal degradation (Hao et al, 2012; Koo et al, …