Some viruses make us sick and are cleared within days by the immune system, but other viruses lurk in our bodies for a lifetime and can re-emerge later to cause new problems. How and why viral levels change in the body over time — and the health impacts of …
Chronic inflammation can raise a person’s risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk. Scientists at the Broad Institute and Harvard University have …
One of the symptoms of schizophrenia is difficulty incorporating new information about the world. This can lead people with schizophrenia to struggle with making decisions and, eventually, to lose touch with reality. Neuroscientists from the Broad …
The Stanley Family Foundation has renewed its commitment to psychiatric research at the Broad Institute, bringing its total investment to more than $1 billion. This funding, including their newest commitment of $280 million to the Stanley Center for …
Most adult body fat consists of white fat cells that store excess calories, but babies are born with stores of brown and beige fat that burn energy to generate heat. Brown fat levels decrease with age, but scientists have long sought to change that, …
An autoimmune disorder that affects the thyroid gland, called autoimmune hypothyroidism (AIHT), is the most common autoimmune disease, yet it remains largely understudied. New research from scientists at Broad Institute, University of Helsinki, and other …
An initiative aimed at improving medical care and addressing chronic disease is now underway in Alabama. Catalyst, a precision medicine program led by the Alabama nonprofit Southern Research in collaboration with Broad Clinical Labs at the Broad Institute …
Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health traits. By probing regions of DNA previously linked to disease, the work has created high resolution maps of DNA variant activity, …
Broad Institute's gene-editing technologies—CRISPR-Cas9, base editing, and prime editing—are being tested in more than 25 clinical trials to treat or cure leukemias, rare genetic diseases, high cholesterol, and other conditions. NIH-funded discoveries …
A genetic test developed by researchers at Broad Clinical Labs and the U.S. Department of Veterans Affairs (VA) is now enabling a large, nationwide clinical trial aimed at improving health care for men at increased risk of developing prostate cancer, the …
Broad Institute core member Feng Zhang, along with 15 other innovators, will be inducted into the National Inventors Hall of Fame. In partnership with the United States Patent and Trademark Office, the Hall of Fame will honor the latest class of inductees …
No matter how much they brush their teeth, some people still get more cavities than others, in part because of differences in genetics and the make-up of the microbes in their mouths. A new study has found human genetic factors that influence the oral …
Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments that can control gene activity in specific cells. These sequences, called cis-regulatory elements (CREs), make up a large part of …
An estimated 3 million Americans have an inflammatory bowel disease (IBD) such as Crohn’s disease or ulcerative colitis. But a lucky few individuals are far less likely to develop IBD because they have a rare variant of a gene called CARD9. This protective …
When inflammation in the body goes unchecked, it can cause fibrosis, or tissue scarring that may lead to organ dysfunction or even failure. This can happen in conditions such as inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), chronic …
One of the biggest risk factors for developing liver cancer is a high-fat diet. A new study from MIT reveals how a fatty diet rewires liver cells and makes them more prone to becoming cancerous. The researchers found that in response to a high-fat diet, …
As people age, their immune system function declines. T cell populations become smaller and can’t react to pathogens as quickly, making people more susceptible to a variety of infections. To try to overcome that decline, researchers at MIT and the Broad …
Friedreich’s ataxia (FA) is a rare but devastating genetic disorder. Those with the condition are often diagnosed between 5 and 15 years of age and live only into their 30s or 40s. There is no widely approved treatment that modifies the disease, and …
Bhattacharya next met with David Liu, Broad core institute member, the Richard Merkin Professor, and Director of the Merkin Institute for Transformative Technologies in Healthcare at Broad. Liu described his team’s efforts to scale up life-saving gene- …
Highlights A new AI model called popEVE can predict how likely each variant in a patient’s genome is to cause disease. The team is testing popEVE in clinical settings to see if it can speed accurate diagnoses of rare, single-variant genetic diseases. The …
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