As people age, their immune system function declines. T cell populations become smaller and can’t react to pathogens as quickly, making people more susceptible to a variety of infections. To try to overcome that decline, researchers at MIT and the Broad …
Friedreich’s ataxia (FA) is a rare but devastating genetic disorder. Those with the condition are often diagnosed between 5 and 15 years of age and live only into their 30s or 40s. There is no widely approved treatment that modifies the disease, and …
Bhattacharya next met with David Liu, Broad core institute member, the Richard Merkin Professor, and Director of the Merkin Institute for Transformative Technologies in Healthcare at Broad. Liu described his team’s efforts to scale up life-saving gene- …
Highlights A new AI model called popEVE can predict how likely each variant in a patient’s genome is to cause disease. The team is testing popEVE in clinical settings to see if it can speed accurate diagnoses of rare, single-variant genetic diseases. The …
Contributions to this project were also made by colleagues in the Broad’s technology platforms, including the Genetic Perturbation Platform, the Center for the Development of Therapeutics, and the Proteomics Platform, and by colleagues in the Broad’s …
The US Food and Drug Administration has approved the first cancer drug based on discoveries from Broad Institute scientists. The drug, sevabertinib, was developed by Bayer Healthcare Pharmaceuticals in close collaboration with the Broad, and is the first …
A team of researchers at the Broad Institute, led by gene-editing pioneer David Liu, has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases. Gene-editing medicines are often …
The John D. and Catherine T. MacArthur Foundation announced today that it has awarded a $100 million, five-year grant to the Sentinel project — a system for detecting outbreaks in real time and preventing them from growing into potential pandemics. Every …
Most people have experienced distressing events in their lives, such as violence, neglect, or natural disasters. These and other kinds of adverse experiences can have dramatic effects on physical and mental health, yet scientists don’t fully understand how …
Dilated cardiomyopathy (DCM), a leading cause of heart failure, is twice as common in Black individuals as in white individuals. This excess risk is not fully explained by known risk factors such as high blood pressure or socioeconomic barriers to care. …
The 2025 Richard N. Merkin Prize in Biomedical Technology was jointly awarded to Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain in a ceremony and symposium at the Broad Institute on September 30, 2025. The prize, created by the Merkin …
An alliance of scientists at the Broad Institute and Bayer Pharmaceuticals have developed a drug candidate, sevabertinib, that could be a new treatment for a group of lung cancer patients who have few options today. In a new study published in Cancer …
Broad Clinical Labs, in collaboration with Roche Sequencing Solutions and Boston Children’s Hospital, today announced official recognition by Guinness World Records for achieving the fastest DNA sequencing technique to date. Leveraging Roche’s new SBX …
In 2015, an innovative research initiative called Count Me In launched to give every patient with cancer, no matter where they lived, a way to contribute directly to research and help accelerate advances that could one day lead to new treatments. Since …
Broad Institute has appointed Jason Buenrostro as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the Epigenomics Program at Broad. Buenrostro is a professor in the …
Researchers from Mass General Brigham and the Broad Institute of MIT and Harvard have identified genetic modifications that can improve the efficacy of chimeric antigen receptor (CAR)-T cell treatment — an immunotherapy that uses modified patient T cells …
Researchers at Dana-Farber Cancer Institute and the Broad Institute have developed an artificial intelligence-based diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided …
Although Gail Guo’s parents had no formal scientific training, she fondly recalls their curiosity and frequent chats about research discoveries during her childhood in China. They also told Gail about her aunt who’d studied chemistry and moved to the US to …
Many of you will have heard by now the sad news that David Baltimore passed away on Saturday morning. The New York Times obituary describes David’s roles as one of the greatest scientists and scientific leaders of his generation. His legendary …
In June, Google DeepMind took the wraps off AlphaGenome, its latest machine learning model for biological discovery. While DeepMind's Nobel Prize-winning AlphaFold model focuses on proteins and how they fold, AlphaGenome predicts how genetic variants …
