Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on September 23, 2025 - 01:55 GMT

New AI-based diagnostic tool uses epigenomics to accelerate acute leukemia diagnosis

Researchers at Dana-Farber Cancer Institute and the Broad Institute have developed an artificial intelligence-based diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided …

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Published on September 11, 2025 - 00:45 GMT

#WhyIScience Q&A: A structural biologist adopts a new role catalyzing collaborations

Although Gail Guo’s parents had no formal scientific training, she fondly recalls their curiosity and frequent chats about research discoveries during her childhood in China. They also told Gail about her aunt who’d studied chemistry and moved to the US to …

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Published on September 9, 2025 - 03:42 GMT

Remembering David Baltimore

Many of you will have heard by now the sad news that David Baltimore passed away on Saturday morning. The New York Times obituary describes David’s roles as one of the greatest scientists and scientific leaders of his generation. His legendary …

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Published on September 4, 2025 - 00:58 GMT

How massive datasets generated at Broad are powering the latest AI models in biology

In June, Google DeepMind took the wraps off AlphaGenome, its latest machine learning model for biological discovery. While DeepMind's Nobel Prize-winning AlphaFold model focuses on proteins and how they fold, AlphaGenome predicts how genetic variants …

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Published on September 4, 2025 - 00:58 GMT

Mass General Brigham launches genetic test to predict risk across eight cardiovascular conditions

In a step forward for genomic-driven preventive medicine, Mass General Brigham Personalized Medicine and the Massachusetts General Hospital’s Cardiovascular Disease Prevention Center and Center for Genomic Medicine today announced the launch of an …

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Published on August 23, 2025 - 05:10 GMT

Breast cancer therapy can raise uterine cancer risk through a unique mechanism

Studies show that people receiving tamoxifen, a highly effective and commonly used therapy to treat breast cancer, face a 2- to 7-fold increased risk of developing uterine cancer within 2-5 years of tamoxifen treatment compared to the general population. …

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Published on August 15, 2025 - 13:02 GMT

Using artificial intelligence, researchers design new compounds that kill antibiotic-resistant bacteria

With help from artificial intelligence, researchers from MIT, the Whitehead Institute for Biomedical Research, the Wyss Institute for Biologically Inspired Engineering, and the Broad Institute of MIT and Harvard have designed novel antibiotics that can …

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Published on August 9, 2025 - 04:02 GMT

Blood-based test provides new diagnostic approach for multiple myeloma

Researchers at Dana-Farber Cancer Institute, Massachusetts General Hospital (MGH), and the Broad Institute have developed a blood test that could transform the diagnosis and monitoring of multiple myeloma (MM) and its precursor conditions. The new method, …

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Published on August 7, 2025 - 15:19 GMT

Boston Children’s Hospital, Dana-Farber Cancer Institute, and Broad Clinical Labs launch precision genomics initiative for ...

In a pioneering collaboration aimed at transforming pediatric cancer diagnostics and research, Boston Children’s Hospital (BCH), Dana-Farber Cancer Institute (DFCI), and Broad Clinical Labs have announced the formation of BrightSeq (Boston Research in …

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Published on August 7, 2025 - 06:08 GMT

Scientists develop technology that brings new precision to genome editing

The FDA’s recent approval of the first CRISPR-Cas9–based gene therapy marked a major milestone in biomedicine, validating genome editing as a promising treatment strategy for disorders like sickle cell disease, muscular dystrophy, and certain cancers. …

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Published on August 6, 2025 - 23:43 GMT

Breathing low-oxygen air slows Parkinson’s progression in mice

Researchers from the Broad Institute and Mass General Brigham have shown that a low-oxygen environment — similar to the thin air found at Mount Everest base camp — can protect the brain and restore movement in mice with Parkinson’s-like disease. The new …

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Published on August 2, 2025 - 03:16 GMT

Genomics points to potential targeted treatment options for pediatric gliomas

A collaborative study between Dana-Farber Cancer Institute and the Broad Institute found that 8.9 percent of children with glioma, the most common form of pediatric brain tumor, have alterations in the fibroblast growth factor receptor (FGFR) family of …

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Published on August 1, 2025 - 04:39 GMT

Study finds biomarkers, drug targets, risk factors for most common form of lung cancer

By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never …

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Published on July 30, 2025 - 05:30 GMT

Collaboration aims to reduce animal use in drug safety testing

Roughly a third of drug candidates fail in the first phase of clinical trials, often due to unanticipated toxic effects that weren’t apparent in animal tests. A consortium co-led by Broad Institute scientists is building tools and datasets to reduce the …

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Published on July 25, 2025 - 08:02 GMT

Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets

Although outbreaks of Ebola virus are rare, the disease is severe and often fatal, with few treatment options. Rather than targeting the virus itself, one promising therapeutic approach would be to interrupt proteins in the human host cell that the virus …

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Published on July 18, 2025 - 05:52 GMT

Seth Klarman selected Chair of the Broad Institute Board of Directors

The Broad Institute announced today that Seth Klarman, prominent business leader, investor, philanthropist, and author, will become the next Chair of the Board of Directors, succeeding Eric Schmidt, who has served as Chair of the Board since 2021. Schmidt, …

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Published on June 26, 2025 - 06:48 GMT

Scientists discover network of cells and genes involved in Crohn’s disease complication

Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut “strictures” is …

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Published on June 25, 2025 - 05:17 GMT

Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases

In May 2025, researchers announced that K.J. Muldoon, a baby boy born without the ability to process dietary protein properly, had become the first person to be treated with a customized gene editing therapy. Based on a technology developed by Broad …

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Published on June 17, 2025 - 02:19 GMT

#WhyIScienceQ&A: A neuroscientist advocates for stepping outside your comfort zone in research

At first, Giulia Monti thought she’d work in another neuroscience lab as a postdoctoral researcher. She had spent the last four years earning her PhD at Aarhus University in Denmark, studying proteins called cargo receptors in Alzheimer’s disease. But then …

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Published on June 11, 2025 - 22:12 GMT

Broad Institute and Bayer extend their cardiovascular alliance

The Broad Institute and Bayer have extended their cardiovascular research collaboration of 10 years by an additional five years, further advancing their work in human genomics research in cardiovascular diseases. First launched in 2015 and renewed in 2020, …

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