Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on May 30, 2025 - 02:04 GMT

New technique expands cells to sequence DNA and capture fine structural details

Broad Institute researchers have developed a technology that provides new insight into how disruptions in the nucleus of the cell can impact health and disease. The approach, called expansion in situ genome sequencing, allows scientists to sequence DNA and …

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Published on May 29, 2025 - 03:24 GMT

Making antibiotics more potent against drug-resistant bacteria

Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of …

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Published on May 28, 2025 - 00:17 GMT

Gene editing disrupts Huntington’s mutation in mice

Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia. The conditions are two of more than 40 severe neurological disorders caused by three-letter stretches of DNA that …

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Published on May 22, 2025 - 03:46 GMT

Scientists create next generation of tools in battle against brain disease

Researchers from around 29 universities and institutions across North America have teamed up to create a large, versatile, and effective arsenal of new biological tools that will play a critical role in the battle against brain disease. The tools are known …

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Published on May 22, 2025 - 03:46 GMT

Genomic score predicts patients' progression to multiple myeloma

A new risk assessment score developed by researchers at Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, and Massachusetts General Hospital reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous …

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Published on May 22, 2025 - 03:46 GMT

2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Four biomedical innovators — Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain — have been jointly awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing chimeric antigen receptor (CAR) T-cell therapy, a …

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Published on May 21, 2025 - 03:47 GMT

Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder

Cancers of the biliary tract system affect the network of ducts that connect the liver, gallbladder, and small intestine, and are aggressive, killing 9 out of 10 patients within just a few years of diagnosis. New research from the Broad Institute and …

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Published on May 20, 2025 - 00:57 GMT

New study aims to uncover the genetics of anorexia and other eating disorders

A new direct-to-participant effort now underway is giving people the opportunity to participate in the largest and most diverse genetic study of anorexia nervosa and other eating disorders to date. Researchers at the Broad Institute Ben Neale and Mark Daly …

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Published on May 20, 2025 - 00:57 GMT

With AI, researchers predict the location of virtually any protein within a human cell

A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can …

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Published on May 16, 2025 - 02:38 GMT

Evolved gene editor inserts entire genes in human cells

Researchers from the Broad Institute and Columbia University have developed a way to insert entire healthy genes into human cells efficiently enough for potential therapeutic applications. It lays a foundation for gene-editing therapies for patients with …

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Published on May 15, 2025 - 19:08 GMT

Cas9 ancestor engineered into a compact genome editing tool

Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The engineered protein, called NovaIscB, can be …

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Published on May 15, 2025 - 16:43 GMT

AI tool predicts potential drug targets by analyzing cell images

A new AI model developed by researchers at the Eric and Wendy Schmidt Center at the Broad Institute and ETH Zurich’s Department of Health Science and Technology can identify genes that have been altered, such as ones that might be causing a disease, in a …

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Published on May 13, 2025 - 12:54 GMT

#WhyIScience Q&A: A systems biologist uses AI to understand how the genome controls cell fate

Growing up in the Sichuan province in China, Bo Xia was curious about the nature he saw around him: the creeks that ran through his hometown and its many animals and insects. In school, he loved imagining how molecules made up materials and whole organisms …

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Published on May 8, 2025 - 01:41 GMT

How the Novo Nordisk Foundation Center at Broad is using scalable technologies and AI to find the root cause of diabetes

Since the earliest days of her scientific career, Melina Claussnitzer, a metabolic disease researcher at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease (NNFC) at the Broad Institute, has been thinking about how to accelerate the …

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Published on May 1, 2025 - 03:37 GMT

Sentinel program among finalists for the $100 Million 100&Change competition

The MacArthur Foundation and its nonprofit affiliate, Lever for Change, have announced the Sentinel program as one of five finalists in the 100&Change competition. 100&Change is a global competition awarding a single $100 million grant to help …

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Published on April 16, 2025 - 16:22 GMT

WhyIScience Q&A: How a chemist moved to the business side of science

Diane Diehl excelled in math and science as a student, but in high school, she also got a taste for business. During summers, she worked at her father’s small engineering firm in Wheeling, Illinois, managing the office, handling payroll, and making sure …

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Published on April 10, 2025 - 21:38 GMT

Potential Alzheimer’s disease therapeutic target identified in brain immune cells

Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset …

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Published on April 6, 2025 - 10:42 GMT

David Liu receives Breakthrough Prize in Life Sciences

Gene editing pioneer David Liu, a core member at the Broad Institute where he is the Richard Merkin Professor and director of the Merkin Institute for Transformative Technologies in Healthcare, has been named a laureate of the 2025 Breakthrough Prize in …

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Published on April 4, 2025 - 03:38 GMT

Scientists have developed a way to scale up spatial genomics and lower costs

Spatial transcriptomics technologies opened the door for new kinds of biological measurements, allowing scientists to generate detailed maps of where genes are expressed in tissue. But most methods rely on expensive and time-intensive imaging that requires …

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Published on March 28, 2025 - 02:17 GMT

A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers

When Maddie Murphy, a computational associate at the Broad Institute of MIT and Harvard, first learned she’d have the opportunity to pursue her research in Copenhagen, she envisioned a two- or three-week visit. Then her supervisor, Ray Jones, told her she …

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