Researchers from the Broad Institute and Mass General Brigham have shown that a low-oxygen environment — similar to the thin air found at Mount Everest base camp — can protect the brain and restore movement in mice with Parkinson’s-like disease. The new …
A collaborative study between Dana-Farber Cancer Institute and the Broad Institute found that 8.9 percent of children with glioma, the most common form of pediatric brain tumor, have alterations in the fibroblast growth factor receptor (FGFR) family of …
By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never …
Roughly a third of drug candidates fail in the first phase of clinical trials, often due to unanticipated toxic effects that weren’t apparent in animal tests. A consortium co-led by Broad Institute scientists is building tools and datasets to reduce the …
Although outbreaks of Ebola virus are rare, the disease is severe and often fatal, with few treatment options. Rather than targeting the virus itself, one promising therapeutic approach would be to interrupt proteins in the human host cell that the virus …
The Broad Institute announced today that Seth Klarman, prominent business leader, investor, philanthropist, and author, will become the next Chair of the Board of Directors, succeeding Eric Schmidt, who has served as Chair of the Board since 2021. Schmidt …
Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut “strictures” is …
In May 2025, researchers announced that K.J. Muldoon, a baby boy born without the ability to process dietary protein properly, had become the first person to be treated with a customized gene editing therapy. Based on a technology developed by Broad …
At first, Giulia Monti thought she’d work in another neuroscience lab as a postdoctoral researcher. She had spent the last four years earning her PhD at Aarhus University in Denmark, studying proteins called cargo receptors in Alzheimer’s disease. But then …
The Broad Institute and Bayer have extended their cardiovascular research collaboration of 10 years by an additional five years, further advancing their work in human genomics research in cardiovascular diseases. First launched in 2015 and renewed in 2020 …
Broad Institute researchers have developed a technology that provides new insight into how disruptions in the nucleus of the cell can impact health and disease. The approach, called expansion in situ genome sequencing, allows scientists to sequence DNA and …
Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of …
Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia. The conditions are two of more than 40 severe neurological disorders caused by three-letter stretches of DNA that …
A new risk assessment score developed by researchers at Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, and Massachusetts General Hospital reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous …
Four biomedical innovators — Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain — have been jointly awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing chimeric antigen receptor (CAR) T-cell therapy, a …
Researchers from around 29 universities and institutions across North America have teamed up to create a large, versatile, and effective arsenal of new biological tools that will play a critical role in the battle against brain disease. The tools are known …
Cancers of the biliary tract system affect the network of ducts that connect the liver, gallbladder, and small intestine, and are aggressive, killing 9 out of 10 patients within just a few years of diagnosis. New research from the Broad Institute and …
A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can …
A new direct-to-participant effort now underway is giving people the opportunity to participate in the largest and most diverse genetic study of anorexia nervosa and other eating disorders to date. Researchers at the Broad Institute Ben Neale and Mark Daly …
Researchers from the Broad Institute and Columbia University have developed a way to insert entire healthy genes into human cells efficiently enough for potential therapeutic applications. It lays a foundation for gene-editing therapies for patients with …
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