Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on March 19, 2024 - 15:00 GMT

Researchers roll out a more accurate way to estimate genetic risks of disease

A new scoring approach featured in Cell Genomics and developed by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) uses a comprehensive approach to generate more accurate and informative PRSs. Aptly named …

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Published on March 14, 2024 - 19:29 GMT

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins

Researchers studying the role of proteins in health and disease use experimental tools that inactivate proteins, destroy them, or prevent them from being made in cells. In one approach, they mark targeted proteins with “destroy me” tags that work with …

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Published on March 8, 2024 - 15:02 GMT

Study reveals genetic clusters that may explain differences in type 2 diabetes risk

The development and progression of type 2 diabetes are affected by numerous biological processes, such as the body’s response to insulin, the health of insulin-producing pancreatic beta cells, and the functioning of metabolic pathways. In a recent study …

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Published on March 8, 2024 - 15:00 GMT

A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Why did you and your colleagues in Senegal decide to do this study? Siddle: This project was somewhat born out of a sense that there was relatively limited diagnostic testing available. Senegalese clinicians told us that lack of diagnostics was a source …

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Published on March 6, 2024 - 16:00 GMT

Schizophrenia and aging may share a common biological basis

Researchers from the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with …

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Published on January 30, 2024 - 10:00 GMT

Battling antibiotic resistance in the lab and the clinic

After his infectious disease training at MGH and Brigham and Women’s Hospital (BWH), Bhattacharyya served as chief resident at MGH and began considering his future as a physician-scientist. He saw how genomic technology had progressed during the seven …

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Published on January 22, 2024 - 15:00 GMT

Q&A: New approaches are needed to find better cancer drug targets

Tumors depend heavily on certain genetic changes to thrive, and researchers have discovered many such “genetic dependencies” as targets for potential new cancer drugs. At the Broad Institute of MIT and Harvard and elsewhere, researchers are also learning …

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Published on January 19, 2024 - 10:00 GMT

Study reveals how some bacterial infections become chronic

In the early 1900s, a cook named Mary Mallon, better known as “Typhoid Mary”, spread Salmonella Typhi, the causative agent of typhoid fever, to dozens of her patrons even though she showed no symptoms. Many people today harbor pathogenic Salmonella …

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Published on January 18, 2024 - 19:00 GMT

Injectable agents could improve liquid biopsy for cancer detection and monitoring

Scientists have developed two agents, made of therapeutic nanoparticles and antibodies, that could be given to patients shortly before a blood draw to allow physicians to better detect tumor DNA in blood using a technology called liquid biopsy. Liquid …

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Published on January 8, 2024 - 11:29 GMT

Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice

Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new vehicle to deliver its machinery into cells in living animals. A team of researchers at the Broad Institute of MIT and Harvard has …

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Published on December 18, 2023 - 15:02 GMT

Q&A: How to jump-start new psychiatric and neurological drug development

Psychiatric and neurological disorders are widespread, yet the pace of drug development for these conditions lags far behind that of heart disease, cancer, and other conditions. Brain disorders are difficult to study and many drug candidates have failed in …

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Published on October 11, 2023 - 15:00 GMT

A research team searches for every gene that helps tumors evade immunotherapy

As Manguso was wrapping up his PhD work in 2017, he, Haining (now at Arsenal Biosciences), and Kathleen Yates, an immunologist in Haining’s lab with a track record of executing large, complex projects, began to think big about the approach they were taking …

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Published on October 4, 2023 - 15:00 GMT

Cancer immunotherapy candidate provokes powerful dual response in cancer and immune cells

Manguso and Kathleen Yates at the Broad co-direct TIDE, which uses CRISPR screens and other tools in animals to systematically uncover genes such as PTPN2 that cancers use to evade immunotherapy. Hakimeh Ebrahimi-Nik, a senior research scientist in TIDE, …

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Published on August 31, 2023 - 15:00 GMT

Evolved prime editors are smaller and more efficient for therapeutic applications

Prime editing technologies allow scientists to precisely edit the genome in a variety of ways and could one day be used to treat genetic diseases. Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory …

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Published on August 31, 2023 - 15:00 GMT

Schizophrenia gene mutation causes many changes in the mouse brain

Researchers have identified common and rare gene mutations that increase risk for schizophrenia. Yet it’s unclear what biological mechanisms go awry in the brain to cause psychosis and other disabling symptoms, due in part to a lack of valid animal models …

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Published on August 14, 2023 - 15:00 GMT

Three studies highlight how proteins are altered in multiple cancer types

Over the past two decades, scientists have shed light on the genetic mutations that drive cancer. More recently, they are focusing on proteins to understand the biological events in cancer cells that lead to disease. In three new studies, researchers …

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Published on July 19, 2023 - 18:00 GMT

Researchers reprogram gene therapy viral vectors to bind specific protein targets

In 2019, Deverman’s group identified the protein that serves as a receptor for AAV-PHP.B, a capsid that is efficiently transported across the blood-brain barrier. That made them wonder whether they could develop a screening approach that would find more …

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Published on June 28, 2023 - 14:42 GMT

How chromosome imbalances can drive cancer

The vast majority of cancer cells have too few or too many copies of some chromosomes, a state known as aneuploidy. But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells’ …

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Published on May 11, 2023 - 19:47 GMT

Survey of brain cell junctions shows striking similarities between schizophrenia and bipolar disorder

Although bipolar disorder and schizophrenia are diagnosed as distinct psychiatric conditions, both are considerably heritable with molecular roots that are poorly understood. Some people diagnosed with one disorder have symptoms and clinical features in …

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Published on April 20, 2023 - 15:05 GMT

Scientists use genetics to dig into a tumor’s past

For patients with some types of cancer, diagnosis can happen at an advanced stage. While a tumor grows unnoticed, it accumulates hundreds to thousands of mutations, making it difficult for scientists studying late-stage cancers to figure out which ones …

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