The vast majority of cancer cells have too few or too many copies of some chromosomes, a state known as aneuploidy. But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells’ …
For patients with some types of cancer, diagnosis can happen at an advanced stage. While a tumor grows unnoticed, it accumulates hundreds to thousands of mutations, making it difficult for scientists studying late-stage cancers to figure out which ones …
One of the newest types of cancer drugs, immunotherapies called immune checkpoint inhibitors, has transformed the treatment of lung cancer over the last decade — dramatically improving the survival of some patients with the most common form of this disease …
Researchers have used a gene-editing technique called base editing to restore motor function to near-normal levels in a mouse model of spinal muscular atrophy (SMA) — a disease that leads to paralysis and, in its most severe form, death before the age of …
Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals. The technology, described …
Late last year, thousands of children across the United States were hospitalized with respiratory syncytial virus (RSV), but unlike previous RSV surges, this one affected a larger number of people and a broader range of age groups, including older children …
Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all …
In a landmark genetic study of more than 121,000 people, an international consortium called SCHEMA, led by researchers at the Broad Institute of MIT and Harvard, has identified extremely rare protein-disrupting mutations in 10 genes that strongly increase …
When a 15-year-old Sumaiya Iqbal was asked about her career aspirations in a televised profile series about the most promising young students in Bangladesh, she confidently responded that she wanted to become “a scientist.” At the time, she was thinking of …
Welcome to the March 15, 2019 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. A data flood from young bloods For a systems biology look at how the human body …
Welcome to the March 8, 2019 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. Exhausted, but still effective It’s unclear how anti-PD1 “checkpoint-blockade” …
