Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on November 5, 2024 - 02:54 GMT

A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity

Like many research endeavors, the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute of MIT and Harvard (NNFC) grew out of a conversation between scientists. Kasper Lage, a Danish-born researcher at Broad, and Niels- …

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Published on October 31, 2024 - 01:15 GMT

Researchers map communities of single cells in metastatic breast cancers

A single biopsy from a metastatic breast cancer tumor contains hundreds of thousands of cells – some cancerous and others part of the complex web of immune cells, blood vessels, and supportive tissue that surround a tumor. Researchers have typically …

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Published on October 29, 2024 - 23:27 GMT

New drug triggers rapid cell death in cancer models

A team of researchers at Broad Institute of MIT and Harvard, in a long-term project that has included industry collaborators at Bayer and Trueline Therapeutics, has developed a compound called BRD-810 that holds promise as a therapeutic candidate for …

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Published on October 28, 2024 - 18:41 GMT

New machine learning-based single-cell search engine makes cell annotation faster, more efficient

One of the first steps for researchers in studying and analyzing single cells is to determine the cells’ identity: what type and subtype of cells are these, and how similar or different are they to previously analyzed cells? Scientists then annotate the …

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Published on October 24, 2024 - 06:26 GMT

Machine learning guides researchers to new synthetic genetic switches

Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. …

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Published on October 24, 2024 - 06:26 GMT

To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

The research team found that Emma and the two other children from unrelated families each lack a chunk of DNA in one copy of a gene called CHASERR. This gene is unlike a traditional gene, which encodes RNA that translates into a protein capable of …

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Published on October 22, 2024 - 00:18 GMT

New diagnostic approach for bacterial infections shows promise in the clinic

For patients with bacterial infections, the sooner they are treated with the appropriate antibiotics, the better they will fare. Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab …

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Published on October 17, 2024 - 20:50 GMT

New diagnostic approach for bacterial infections shows promise in the clinic

For patients with bacterial infections, the sooner they are treated with the appropriate antibiotics, the better they will fare. Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab …

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Published on October 16, 2024 - 18:07 GMT

F. William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce ...

The 2024 Richard N. Merkin Prize in Biomedical Technology was awarded to F. William Studier of Brookhaven National Laboratory in a ceremony and symposium at the Broad Institute on September 17, 2024. The prize, created by the Merkin Family Foundation and …

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Published on October 15, 2024 - 23:46 GMT

#WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms

Though his focus shifted over time, being a scientist was always the plan for Eric Brown since kindergarten. “First it was dinosaurs and whales, and then it turned into birds, and then it turned into microbes,” he said. Years later, Brown began studying …

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Published on October 3, 2024 - 22:12 GMT

Largest-ever genetic study of epilepsy finds possible therapeutic targets

The largest and most diverse study to date of epilepsy’s genetic factors has revealed new potential targets for treatment, both shared by and unique to different subtypes of epilepsy. The findings point to factors involved in how neurons communicate and …

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Published on September 30, 2024 - 21:53 GMT

Q&A: How Terra became a backbone of public health pathogen surveillance

DP: Before Terra, only a handful of state public health labs were analyzing their own genomic data. Most didn't really have a way to do large-scale genomic analysis well. Many relied on the CDC, a neighboring state lab, or an academic partner to assist …

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Published on September 23, 2024 - 17:23 GMT

New approach may yield modified messenger RNAs for treating a wide range of conditions

The life-saving use of messenger RNA (mRNA) in COVID-19 vaccines was a public example of the potential of mRNA-based therapies, which hold great promise for a wide range of treatment applications from cancer immunotherapy to gene editing. Working toward a …

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Published on September 18, 2024 - 17:06 GMT

Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time. Gram-negative bacteria such as …

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Published on September 17, 2024 - 15:28 GMT

#WhyIScienceQ&A: A data scientist helps researchers solve computational problems

A desire to constantly learn more has fueled Edana Martin’s varied career in science. Growing up in Colombia, she became fascinated with physics and astronomy, seeking to understand how the world around her works. Martin studied nuclear physics and …

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Published on September 5, 2024 - 21:58 GMT

Q&A: Single-cell and spatial proteomics reveal proteins’ nuanced roles in health and disease

When Steve Carr, senior director of the Proteomics Platform at the Broad Institute of MIT and Harvard, began working in proteomics, the field was able to detect only the most abundant proteins in a given sample. In recent years, increasingly sensitive mass …

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Published on August 20, 2024 - 21:18 GMT

#WhyIScience Q&A: A systems biologist develops computational tools to bring scale to cell experiments

At first, Yue Qin thought she wanted to become a doctor. She’d always been interested in disease — why people got sick, why some illnesses could send you to a hospital while others could be treated at home. As she grew older, however, she realized she was …

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Published on August 19, 2024 - 21:51 GMT

A common fatty acid may help restore healthy vaginal bacteria after infection

More than half of women globally experience bacterial vaginosis (BV) — an imbalance of naturally occurring microbes in the female genital tract — at least once in their life. The condition can cause painful symptoms and vaginal discharge, and although …

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Published on August 8, 2024 - 01:13 GMT

Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy

Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno- …

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Published on August 7, 2024 - 18:06 GMT

Six scientists named as new core institute members at Broad

Broad Institute of MIT and Harvard has named six new core institute members: Gad Getz, Anna Greka, Nir Hacohen, Evan Macosko, Benjamin Neale, and Pardis Sabeti. “We are thrilled to recognize these distinguished scientists for their track record of …

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