Peripheral immune system modulates Purkinje cell degeneration in Niemann-Pick disease type C1
Introduction Niemann–Pick disease type C (NPC) is an autosomal recessive lysosomal storage disorder (LSD) affecting an estimated 1 in 120,000 newborns worldwide (Vanier, 2010). Mutations in NPC1 can be found in ∼95% of NPC patients, although the gene’s …