USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms
Introduction Neurodevelopmental disorders with intellectual disability (ND/ID) are highly incapacitating conditions that affect 2–3% of the population (Leonard & Wen, 2002; Schalock et al, 2007; Maulik et al, 2011). Among these, ∼15% are X-linked ( …