This case involves the power of States to protect vulnerable populations and the integrity of the medical profession. Thus, the States have a particular interest in the issue. In addition, several of the amici States have enacted laws similar to the challenged Missouri law regulating Down-syndrome-selective abortions. Ohio, in particular, successfully defended its law before the en banc Sixth Circuit, and the law has now been in effect for several months. Preterm-Cleveland v. McCloud, 994 F.3d 512 (6th Cir. 2021) (en banc). In sum, the amici States have a strong interest in, and relevant knowledge about, the question presented.