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Human medicines European public assessment report (EPAR): Talvey, talquetamab, Multiple Myeloma, Date of authorisation: 21/08/2023, Status: Authorised

For the full list of side effects and restrictions with Talvey, see the package leaflet.

The most common side effects with Talvey (which may affect more than 6 in 10 people) include cytokine release syndrome (CRS), dysgeusia (taste disturbance) and hypogammaglobulinaemia (low levels of antibodies in the blood). More than 2 in 10 people may be affected by the following side effects: nail disorder, pain in muscles and bones, anaemia (low levels of red blood cells), skin disorder, tiredness, decreased weight, rash, dry mouth, neutropenia (low levels of neutrophils, a type of white blood cell that fights infection), fever, xerosis (severely dry skin), thrombocytopenia (low levels of blood platelets), nose and throat infection, lymphopenia (low levels of lymphocytes, a type of white blood cell), dysphagia (difficulty swallowing), diarrhoea, pruritus (itching), cough, pain, decreased appetite and headache.

Serious side effects include CRS, fever, immune effector cell-associated neurotoxicity syndrome (ICANS, a neurological disorder with symptoms including problems with speech and writing, confusion and depressed level of consciousness), sepsis (blood poisoning), COVID 19, bacterial infection, pneumonia (lung infection), viral infection, neutropenia and pain.

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