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Published on April 20, 2025 - 12:29 GMT

Nrf2 Identified as a Key Driver of Treatment Resistance in Osteosarcoma

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance. …

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Published on April 20, 2025 - 12:29 GMT

MicroRNAs Offer New Hope in the Battle Against Adipose Tissue Fibrosis

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely …

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Published on April 20, 2025 - 12:28 GMT

The Role of Lipid Metabolism in Breast Cancer Progression and Treatment Resistance

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC …

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Published on April 20, 2025 - 12:28 GMT

A New Path in Pancreatic Cancer Treatment: The Therapeutic Promise of GOT2

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal …

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Published on April 20, 2025 - 12:26 GMT

The Emerging Role of Citrullination in Gene Control and Therapeutic Innovation

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease. This process, driven by …

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Published on April 20, 2025 - 12:24 GMT

Mapping the Genetic and Therapeutic Landscape of Anaplastic Thyroid Cancer

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge. A recent review published in Genes & Diseases offers a …

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Published on April 20, 2025 - 12:24 GMT

Cellular Pathways and Treatment Frontiers of Achondroplasia

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the …

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Published on April 2, 2025 - 12:10 GMT

YTHDF1 Identified As a Potential Therapeutic Target for Autoimmune Hepatitis

New Study Underscores The Pivotal Role Of YTHDF1 In Immune-Mediated Hepatitis CHINA, April 2, 2025 /⁨EINPresswire.com⁩/ -- Autoimmune hepatitis (AIH) is a severe autoimmune disease characterized by immune-mediated hepatocyte destruction, leading to …

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Published on March 28, 2025 - 12:24 GMT

Sexual Dimorphism in Cystinuria- The Mitochondria Link

Unravelling the role of mitochondrial Slc3a1 in regulating mitochondrial functions and sexual dimorphism in cystinuria CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Cystinuria is the most common inheritable cause of kidney stone disease, characterized by …

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Published on March 28, 2025 - 12:00 GMT

Comprehensive Genomic and Epigenomic Characterization of Iridocorneal Endothelial Syndrome

New Study Unravels The Underlying Mechanisms Of ICE Syndrome CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Iridocorneal endothelial (ICE) syndrome is a rare, irreversibly blinding ocular disorder with an unknown etiology. Lack of targeted effective drugs …

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Published on March 28, 2025 - 11:48 GMT

Inhibiting Sphingosine-1-Phosphate Receptor 3 (S1PR3) Mitigates Pulmonary Fibrosis

S1pr3 knockdown ameliorates bleomycin-induced pulmonary fibrosis by reducing macrophage M2 polarization CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Pulmonary fibrosis (PF) involves the excessive accumulation of extracellular matrix, resulting in the …

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Published on March 28, 2025 - 11:48 GMT

High-Mobility Group Nucleosomal-Binding Domain 2: A Prognostic Indicator and A New Therapeutic Target for Gliomas

New Study Unveils Novel Direction For The Treatment Of Glioblastoma Multiforme CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Glioblastoma multiforme (GBM), commonly referred to as glioblastoma, is a malignant intracranial tumor derived from glial cells, …

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Published on March 18, 2025 - 08:15 GMT

Isoleucyl-tRNA Synthetase 2 (IARS2) Promotes Pancreatic Ductal Adenocarcinoma (PDAC)

IARS2 facilitates PDAC proliferation and metastasis by stabilizing β-catenin and activating the WNT/β-catenin pathway. CHINA, March 18, 2025 /⁨EINPresswire.com⁩/ -- Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related …

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Published on March 18, 2025 - 07:51 GMT

Immune Subtyping and NK Cell Targeting: Optimizing Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma

- New Study Unveils Novel Classification Approach for Predicting ICI Response in HCC Patients CHINA, March 18, 2025 /⁨EINPresswire.com⁩/ -- Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, accounts for about 75–85% of all …

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Published on March 17, 2025 - 11:21 GMT

Transcriptional Landscape of PDAC Shows Distinct Cell Populations

Single-cell RNA sequencing (scRNA-seq) on a PDAC cohort identified distinct cell populations associated with tumor initiation and progression CHINA, March 17, 2025 /⁨EINPresswire.com⁩/ -- Pancreatic cancer is one of the leading causes of cancer-related …

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Published on March 17, 2025 - 11:08 GMT

SPP1+ Macrophages Identified as Key Drivers and Therapeutic Targets In Colorectal Cancer Progression

New Study Unveils Critical Role of SPP1+ Macrophages in Colorectal Cancer Progression and Treatment CHINA, March 17, 2025 /⁨EINPresswire.com⁩/ -- Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related …

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Published on March 13, 2025 - 13:03 GMT

IL2RG Gene Therapy for X-SCID

Pre-clinical validation of SIN-EFS-IL2RG.co vector-based gene therapy for X-SCID CHINA, March 13, 2025 /⁨EINPresswire.com⁩/ -- X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in T- …

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Published on March 13, 2025 - 12:38 GMT

Innovative Study Highlights BMP9 and SHH as Key Drivers of Bone Repair

New Research Highlights Synergistic Role of BMP9 and Shh in Bone Regeneration CHINA, March 13, 2025 /⁨EINPresswire.com⁩/ -- Bone morphogenetic proteins (BMPs) directly affect the osteogenic differentiation of stem cells and are integral to bone tissue …

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Published on March 11, 2025 - 06:20 GMT

Delineating the Mechanisms Mediating Piezo-1- Induced Liver Regeneration

Theoretical basis for mechanical stimulation-mediated chemical signals-induced liver regeneration CHINA, March 11, 2025 /⁨EINPresswire.com⁩/ -- Liver regeneration (LR) is a complex biological process involving the proliferation of parenchymal (hepatocytes …

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Published on March 11, 2025 - 06:01 GMT

AI-Driven Advancements in Neuroblastoma Diagnosis and Bone/Bone Marrow Metastasis Prediction

Groundbreaking Study Unveils Key Mechanisms in Neuroblastoma Bone and Bone Marrow Metastasis CHINA, March 11, 2025 /⁨EINPresswire.com⁩/ -- Neuroblastoma (NB), the most prevalent extracranial solid tumor among children, is characterized by a high rate of …

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