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Published on February 2, 2026 - 18:44 GMT

Flipons help Intrinsically Disordered Proteins Fold into Cellular Machines

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of genetic information CHARLESTOWN, MA, UNITED STATES, February 2, 2026 /⁨EINPresswire.com⁩/ -- In a paper published today, researchers at …

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Published on December 30, 2025 - 06:13 GMT

The Dynamic Targeting of Regulatory Proteins to Genes

Further Roles for Left-Handed Z-DNA in Gene Regulation CHARLESTOWN, MA, UNITED STATES, December 30, 2025 /⁨EINPresswire.com⁩/ -- Combining parts in different ways can lead to product diversity. The challenge then becomes delivering the assembled product …

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Published on December 19, 2025 - 20:29 GMT

A G-quadruplex-hemin peroxidase complex as a source of oxidative stress in neurological diseases

CHARLESTOWN, MA, UNITED STATES, December 19, 2025 /⁨EINPresswire.com⁩/ -- In a paper just published in the journal Antioxidants, the expansion of disease-causing DNA repeats is linked to the formation of a complex that generates superoxide anions toxic to …

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Published on October 22, 2025 - 05:00 GMT

No longer controversial: a new biological role for Z-DNA in cells

People gave up looking for left-handed Z-DNA-binding proteins long ago. This paper shows that many Z-DNA-binding proteins exist in a cell. CHARLESTOWN, MA, UNITED STATES, October 22, 2025 /⁨EINPresswire.com⁩/ -- Since its discovery, the role of left- …

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Published on October 13, 2025 - 15:00 GMT

Cells make Z-RNAs as the first line of defense against pathogenic viruses

Viruses attack by taking control of a cell. To avoid becoming a virus factory, infected cells trigger rapid cell death by producing Z-RNAs made from "junk" DNA. CHARLESTOWN, MA, UNITED STATES, October 13, 2025 /⁨EINPresswire.com⁩/ -- In a paper …

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Published on April 25, 2025 - 12:19 GMT

Biological roles for three strand DNA and RNA flipon structures

The cell's version of the multiverse! Here, the focus is on three-stranded DNA and RNA triplex structures. Their biological relevance is now coming into focus. CHARLESTOWN, MA, UNITED STATES, April 25, 2025 /⁨EINPresswire.com⁩/ -- A paper released on …

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Published on March 26, 2025 - 00:00 GMT

Programming Genomes, the next AI frontier

Recent advances show that genomes are programmable in ways never previously imagined and amenable to AI implementations CHARLESTOWN, MA, UNITED STATES, March 26, 2025 /⁨EINPresswire.com⁩/ -- We all learned that genomes are made up of B-DNA. The idea that …

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Published on March 11, 2025 - 00:45 GMT

G-Flipons promise to improve the therapeutic efficacy of RNA editing

The paper resolves many unanswered questions about the recoding of RNAs by ADAR1 and the outcomes produced in a cell CHARLESTOWN, MA, UNITED STATES, March 11, 2025 /⁨EINPresswire.com⁩/ -- The double-stranded RNA editing enzyme ADAR1 offers excellent …

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Published on January 22, 2025 - 00:05 GMT

New insights in the origins of the genetic code

Where did the modern genetic code come from? The paper provides a surprising answer whereby unusual DNA structures called flipons map codons to amino acids. CHARLESTOWN, MA, UNITED STATES, January 22, 2025 /⁨EINPresswire.com⁩/ -- One of the last remaining …

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Published on September 25, 2024 - 21:16 GMT

New Paper Reveals Radical Change in Our Understanding of DNA Structure and Function

G-flipons cycle conformation and act as digital switches to control the readout of genetic information from DNA. They exchange energy for information. CHARLESTOWN, MA, UNITED STATES, September 25, 2024 /⁨EINPresswire.com⁩/ -- A groundbreaking paper has …

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Published on September 20, 2024 - 17:06 GMT

Memory loss in disease from neuroinflammation due to junk RNA

A different mechanism for causation of Alzheimer's disease, with the protein aggregates now targeted therapeutically produced by downstream pathways CHARLESTOWN, MA, UNITED STATES, September 20, 2024 /⁨EINPresswire.com⁩/ -- One of the surprising …

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Published on June 19, 2024 - 00:20 GMT

Study reveals that our ancient single cell ancestors fought off giant viruses with Z-DNA and Z-RNA

The role of the left-handed Z-DNA and Z-RNA conformation in human immunity has been long overlooked due to an over reliance on fly and worm genetic models CHARLESTOWN, MA, UNITED STATES, June 19, 2024 /⁨EINPresswire.com⁩/ -- In a paper just published in …

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Published on May 29, 2024 - 20:47 GMT

Different Diseases Involve Distinct Biochemical Scaffolds, None of Which are Genetically Templated

A different way of understanding the relationship between egenes and disease CHARLESTOWN, MA, UNITED STATES, May 29, 2024 /⁨EINPresswire.com⁩/ -- In a paper just published in the well-regarded Genes and Immunity, Alan Herbert addresses the question of how …

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Published on May 16, 2024 - 21:21 GMT

An update on the link between bacteria and autoimmune disease

An update on the growing connection between our bacterial microbiome and chronic autoimmune disease CHARLESTOWN, MA, UNITED STATES, May 16, 2024 /⁨EINPresswire.com⁩/ -- From the time of its discovery, people have been intrigued about the unusual form of …

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Published on March 23, 2024 - 21:50 GMT

Recent Discoveries Reveal Many Suprises in How the Genome Encodes Information

While a book about recent genetic discovery seems out of reach for most, this book captures aspects of the process many curious individuals can relate with. CHARLESTOWN, MA, UNITED STATES, March 23, 2024 /⁨EINPresswire.com⁩/ -- Though not as racy as a …

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Published on November 20, 2023 - 04:45 GMT

Flipons within Junk DNA Enhance Biological Computations by Exchanging Energy for Information

Junk DNA enhances evolution by changing how information is read out from the genome CHARLESTOWN, MA, UNITED STATES, November 19, 2023 /⁨EINPresswire.com⁩/ -- Dr. Alan Herbert from InsideOutBio describes how biological systems compute differently from our …

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Published on November 18, 2023 - 22:31 GMT

When the Genome Gets it Wrong, but Still Gets it Right

Current Computation Approaches do not model Biological Systems very well. CHARLESTOWN, MA, UNITED STATES, November 18, 2023 /⁨EINPresswire.com⁩/ -- Dr. Alan Herbert from InsideOutBio describes how biological systems compute differently from our current …

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Published on August 7, 2023 - 04:01 GMT

Flipons are tiny DNA actuators that play a previously unknown role in gene expression

Everything you wanted to know about the role of flipons in DNA transcription but were afraid to ask CHARLESTOWN, MA, UNITED STATES, August 7, 2023 /⁨EINPresswire.com⁩/ -- In a paper just online at the Journal of Biological of Biological Chemistry, Alan …

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Published on July 17, 2023 - 02:53 GMT

Flipons help ADAR1 turn off inflammation

More evidence for a role of Z-RNA in human disease CHARLESTOWN, MA, UNITED STATES, July 16, 2023 /⁨EINPresswire.com⁩/ -- In a paper just published in Cell Reports, evidence id produced that flipons suppress interferon responses by the double-stranded RNA …

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Published on May 12, 2023 - 07:10 GMT

Mapping Z-DNA in the Human Genome to Disease Outcomes

Z-DNA and its function CHARLESTOWN, MA, UNITED STATES, May 12, 2023 /⁨EINPresswire.com⁩/ -- In a paper just published online in the Life Science Alliance entitled “Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease”, …

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