Broad Institute of MIT and Harvard Press Releases

• Published on May 11, 2023 - 19:47 GMT

  

  Survey of brain cell junctions shows striking similarities between schizophrenia and bipolar disorder

  Although bipolar disorder and schizophrenia are diagnosed as distinct psychiatric conditions, both are considerably heritable with molecular roots that are poorly understood. Some people diagnosed with one disorder have symptoms and clinical features in …

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• Published on April 20, 2023 - 15:05 GMT

  

  Scientists use genetics to dig into a tumor’s past

  For patients with some types of cancer, diagnosis can happen at an advanced stage. While a tumor grows unnoticed, it accumulates hundreds to thousands of mutations, making it difficult for scientists studying late-stage cancers to figure out which ones …

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• Published on April 18, 2023 - 14:51 GMT

  

  Lung cancer’s molecular features shed light on immunotherapy response

  One of the newest types of cancer drugs, immunotherapies called immune checkpoint inhibitors, has transformed the treatment of lung cancer over the last decade — dramatically improving the survival of some patients with the most common form of this disease …

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• Published on March 30, 2023 - 18:00 GMT

  

  Base editing treats spinal muscular atrophy in mice

  Researchers have used a gene-editing technique called base editing to restore motor function to near-normal levels in a mouse model of spinal muscular atrophy (SMA) — a disease that leads to paralysis and, in its most severe form, death before the age of …

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• Published on March 29, 2023 - 15:00 GMT

  

  Bacterial injection system delivers proteins in mice and human cells

  Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals. The technology, described …

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• Published on February 22, 2023 - 22:00 GMT

  

  Several pre-existing RSV lineages powered the 2022 surge

  Late last year, thousands of children across the United States were hospitalized with respiratory syncytial virus (RSV), but unlike previous RSV surges, this one affected a larger number of people and a broader range of age groups, including older children …

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• Published on October 31, 2022 - 16:53 GMT

  

  First large genetic study of bipolar disorder in Asian populations launches

  Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all …

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• Published on April 6, 2022 - 17:57 GMT

  

  Researchers find first strong genetic risk factor for bipolar disorder

  The main treatment for bipolar disorder, lithium, was approved a half-century ago but doesn't help all patients and has significant side effects. Little progress has been made in finding better therapies, in part because scientists don’t fully …

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• Published on April 6, 2022 - 15:00 GMT

  

  Two large studies reveal genes and genome regions that influence schizophrenia risk

  In a landmark genetic study of more than 121,000 people, an international consortium called SCHEMA, led by researchers at the Broad Institute of MIT and Harvard, has identified extremely rare protein-disrupting mutations in 10 genes that strongly increase …

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• Published on March 21, 2019 - 10:00 GMT

  

  Academic institutions grant license for CRISPR-based SHERLOCK in developed world, protect rights for use in developing world

  A group of academic institutions has granted a license for SHERLOCK™, the highly-sensitive, low-cost CRISPR-based diagnostic, for commercial uses in the developed world, while reserving rights to enable its broad use by organizations to serve developing …

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• Published on March 18, 2019 - 04:05 GMT

  

  Sumaiya Iqbal is using computer science to bridge genetics and therapeutics

  When a 15-year-old Sumaiya Iqbal was asked about her career aspirations in a televised profile series about the most promising young students in Bangladesh, she confidently responded that she wanted to become “a scientist.” At the time, she was thinking of …

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• Published on March 15, 2019 - 17:21 GMT

  

  Research Roundup: March 15, 2019

  Welcome to the March 15, 2019 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. A data flood from young bloods For a systems biology look at how the human body …

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• Published on March 8, 2019 - 16:48 GMT

  

  Research Roundup: March 8, 2019

  Welcome to the March 8, 2019 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. Exhausted, but still effective It’s unclear how anti-PD1 “checkpoint-blockade” …

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