In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). Broad …
Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat disease has been hampered in part by the lack of precise …
During her highly unusual college experience traveling the world, Wolu Chukwu saw the power of communities. She attended Minerva University, a San Francisco-based college that rotates its students to a different country each semester while they take online …
As a young researcher-in-training at Harvard, chemical biologist Sami Farhi helped develop an innovative technology that can visualize the electrical activity of brain cells. Near the end of his graduate studies in 2018, he lamented the fact that …
Gliomas are the most common brain tumors, and many start off growing slowly as “low-grade” tumors before inevitably becoming aggressive, lethal, and “high grade.” New research offers an explanation for this deadly transformation. In a study published in …
The intestine maintains a delicate balance in the body, absorbing nutrients and water while maintaining a healthy relationship with the gut microbiome, but this equilibrium is disrupted in parts of the intestine in conditions such as celiac disease, …
Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis. Researchers led by physicians and scientists at the Broad Institute of MIT and Harvard and …
In the mid-2010s, oncologist Kerry Reynolds and colleagues at Mass General Hospital noticed an alarming pattern: more and more patients undergoing cancer treatment were coming to the hospital gravely ill, not from the cancer but from the medicine itself. …
Like many research endeavors, the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute of MIT and Harvard (NNFC) grew out of a conversation between scientists. Kasper Lage, a Danish-born researcher at Broad, and Niels- …
A single biopsy from a metastatic breast cancer tumor contains hundreds of thousands of cells – some cancerous and others part of the complex web of immune cells, blood vessels, and supportive tissue that surround a tumor. Researchers have typically …
A team of researchers at Broad Institute of MIT and Harvard, in a long-term project that has included industry collaborators at Bayer and Trueline Therapeutics, has developed a compound called BRD-810 that holds promise as a therapeutic candidate for …
One of the first steps for researchers in studying and analyzing single cells is to determine the cells’ identity: what type and subtype of cells are these, and how similar or different are they to previously analyzed cells? Scientists then annotate the …
Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. …
The research team found that Emma and the two other children from unrelated families each lack a chunk of DNA in one copy of a gene called CHASERR. This gene is unlike a traditional gene, which encodes RNA that translates into a protein capable of …
For patients with bacterial infections, the sooner they are treated with the appropriate antibiotics, the better they will fare. Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab …
For patients with bacterial infections, the sooner they are treated with the appropriate antibiotics, the better they will fare. Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab …
The 2024 Richard N. Merkin Prize in Biomedical Technology was awarded to F. William Studier of Brookhaven National Laboratory in a ceremony and symposium at the Broad Institute on September 17, 2024. The prize, created by the Merkin Family Foundation and …
Though his focus shifted over time, being a scientist was always the plan for Eric Brown since kindergarten. “First it was dinosaurs and whales, and then it turned into birds, and then it turned into microbes,” he said. Years later, Brown began studying …
The largest and most diverse study to date of epilepsy’s genetic factors has revealed new potential targets for treatment, both shared by and unique to different subtypes of epilepsy. The findings point to factors involved in how neurons communicate and …
DP: Before Terra, only a handful of state public health labs were analyzing their own genomic data. Most didn't really have a way to do large-scale genomic analysis well. Many relied on the CDC, a neighboring state lab, or an academic partner to assist …
