Alzheimer’s Disease Therapeutics Market to Reach US$ 30.8 Billion by 2033

Alzheimer’s Disease Therapeutics Market Size

Alzheimer’s Disease Therapeutics Market Size

Alzheimer’s Disease Therapeutics Market Share

Alzheimer’s Disease Therapeutics Market Share

Alzheimer’s Disease Therapeutics Market Regions

Alzheimer’s Disease Therapeutics Market Regions

Global Alzheimer’s Disease Therapeutics Market Size is expected to be worth around USD 30.8 Billion by 2033 from USD 5.5 Billion in 2023.

North America dominated the global Alzheimer’s disease therapeutics market with a revenue share of 42.5%”
— Tajammul Pangarkar
NEW YORK, NY, UNITED STATES, January 23, 2025 /EINPresswire.com/ -- The Global Alzheimer’s Disease Therapeutics Market Size is projected to expand significantly, with expectations to rise from USD 5.5 billion in 2023 to USD 30.8 billion by 2033, at a compound annual growth rate (CAGR) of 18.8%. This growth is primarily fueled by breakthroughs in treatment approaches and advanced drug development aimed at combating the complex pathology of Alzheimer’s disease.

Innovative treatments focusing on Disease-Modifying Therapies (DMTs) are pivotal in this expansion. These therapies, targeting core disease mechanisms such as amyloid plaques, are critical. Notable drugs like lecanemab and donanemab have demonstrated potential in slowing the progression of cognitive decline, especially in early disease stages. This shift towards modifying disease progression rather than merely managing symptoms signifies a transformative approach in Alzheimer’s treatment strategies.

Another significant growth driver is the integration of cardiovascular health with cognitive health, recognizing that heart health directly impacts brain function. This holistic approach emphasizes the importance of managing cardiovascular risk factors like blood pressure and cholesterol levels to possibly delay the onset of Alzheimer's. Furthermore, the trend towards personalized medicine is gaining traction, with genetic testing playing a crucial role in tailoring treatments to individuals’ genetic profiles, enhancing treatment efficacy and safety.

The sector also benefits from advanced clinical trials and robust international research collaborations, which facilitate the rapid development and evaluation of new therapies. Regulatory bodies like the U.S. FDA are instrumental in this progress, fast-tracking the approval of promising treatments. These collaborative and regulatory advancements are crucial in fostering an environment conducive to innovation and effective treatment solutions in Alzheimer’s disease therapeutics.
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Key Takeaway
• In 2023, the Alzheimer’s disease therapeutics market was valued at USD 5.5 billion, projected to reach USD 30.8 billion by 2033.
• The market is growing at a compound annual growth rate (CAGR) of 18.8% from 2024 to 2033.
• North America holds the largest share of the Alzheimer's therapeutics market, with 42.5% of global revenue in 2023.
• The increase in Alzheimer’s cases and the introduction of new treatments are key drivers of market growth.
• More than 6.2 million Americans aged 65 and older were living with Alzheimer’s in 2021, expected to double by 2060.
• The growing number of older adults significantly influences the market expansion for Alzheimer's treatments.
• Enhanced diagnostic tools are enabling earlier and more precise diagnoses of Alzheimer’s disease.
• Alzheimer's disease's complexity and varied causes present significant challenges in drug development.
• A high failure rate of Alzheimer’s drug candidates in clinical trials discourages further investment and research.
• Cholinesterase inhibitors lead the Alzheimer’s treatment market, representing 53.2% of it in 2023.
• Mild cognitive impairment (MCI) was the most prevalent disease stage in 2023, with a 33.7% market share.
• Oral medications are the most common form of Alzheimer’s treatment, accounting for 58.1% of the market in 2023.
• Hospital pharmacies are the primary distribution channel for these medications, holding a 56.4% market share in 2023.

Segmentation Analysis
In 2023, the Alzheimer's Disease Therapeutics market identified cholinesterase inhibitors as its leading segment, capturing a 53.2% revenue share. These drugs, which are the standard treatment for Alzheimer’s disease (AD), inhibit the breakdown of acetylcholine, a crucial neurotransmitter in memory and cognitive functions. Their effectiveness has driven their prevalence as a primary treatment option, while the pipeline drugs segment is expected to grow rapidly due to anticipated launches of disease-modifying therapies.

Mild cognitive impairment (MCI) was the predominant disease stage in 2023, accounting for 33.7% of the market. Common in older adults, MCI's prevalence increases with age, affecting up to 37% of individuals aged 85 and older. Although not all MCI cases progress to Alzheimer's, its significant presence impacts the therapeutic landscape, as reported by the American Academy of Neurology.

Orally administered drugs held the largest revenue share at 58.1% in 2023, primarily due to the widespread use of cholinesterase inhibitors like donepezil and memantine. The convenience of oral administration, allowing patients to manage their medication independently at home or while traveling, supports this segment's dominance. This route's ease and non-invasive nature make it preferable for continuous management of AD.

Hospital pharmacies led the distribution channels, accounting for 56.4% of the market in 2023. This dominance is attributed to the high hospitalization rates of AD patients and the growing geriatric population, which consequently increases AD drug sales through these facilities. According to a 2022 Alzheimer’s Association report, Alzheimer's patients see significantly higher hospitalization rates compared to non-dementia counterparts, highlighting the critical role of hospital pharmacies in medication distribution.

By Drug Class
• Cholinesterase inhibitors
• NMDA Receptor Antagonist
• Combination Drug
• Pipeline Drugs

By Disease Stage
• Preclinical Alzheimer's disease
• Mild cognitive impairment (MCI)
• Mild dementia due to AD
• Moderate dementia due to AD
• Severe dementia due to AD

By Route of Administration
• Oral
• Injectable

By Distribution Channel
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

Regional Analysis
In 2023, North America held the largest revenue share of the global Alzheimer’s disease therapeutics market, accounting for 42.5%. This dominant position is mainly due to extensive research efforts aimed at developing treatments for Alzheimer's disease. Additionally, the region benefits from robust government initiatives and significant funding aimed at tackling this medical challenge.

The significant market share is further bolstered by the U.S. Food and Drug Administration’s actions. In June 2021, the FDA awarded Breakthrough Therapy designation to lecanemab (BAN2401). This treatment, an anti-amyloid beta protofibril antibody, is being developed by Eisai Co., Ltd. and Biogen, marking a significant milestone in Alzheimer’s disease treatment initiatives in the region.

Meanwhile, the Alzheimer’s disease therapeutics market in the Asia-Pacific region is projected to grow at the highest Compound Annual Growth Rate (CAGR) during the forecast period. The growth is primarily driven by escalating research activities aimed at discovering novel drugs for Alzheimer's treatment.

Additionally, increasing awareness about Alzheimer’s disease within the Asia-Pacific region is expected to further stimulate market growth. Public and health professional awareness campaigns are enhancing understanding of the disease, thereby encouraging early diagnosis and treatment, which fuels the regional market’s expansion.

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Market Players Analysis
Emerging key players in the Alzheimer's disease treatment market are heavily investing in research and development to introduce novel drugs and therapies. These innovations aim to address the complex challenges of Alzheimer’s, with a strong focus on drugs that can reduce amyloid-β plaques and slow cognitive decline in early-stage patients. This strategic focus is anticipated to significantly drive market growth during the forecast period.

Additionally, these companies are actively pursuing growth strategies including partnerships, collaborations, and mergers & acquisitions. Such strategic actions are designed to enhance their market presence and capitalize on emerging opportunities in the rapidly evolving Alzheimer's treatment landscape.

Among the successful outcomes of these strategies is the launch of therapies that demonstrate moderate success in slowing mild cognitive impairment associated with early Alzheimer’s. These advancements are crucial as they contribute to the overall expansion of treatment options, offering hope and improved outcomes for patients.

Key players leading these innovations include Eisai Co., Ltd., Novartis AG, AbbVie Inc. (Allergan Plc.), Adamas Pharmaceuticals, Inc., and Lundbeck A/S. Other notable companies like Biogen, AC Immune, Hoffmann La Roche Ltd., Daiichi Sankyo Company, Limited, Johnson & Johnson Services, Inc., and TauRx Pharmaceuticals Ltd. also play significant roles in the market dynamics, alongside other emerging entities.

The Primary Entities Identified In This Report Are:

• Eisai Co. Ltd.
• Novartis AG
• AbbVie Inc. (Allergan Plc.)
• Adamas Pharmaceuticals Inc.
• Lundbeck A/S
• Biogen
• AC Immune
• Hoffmann La Roche Ltd.
• Daiichi Sankyo Company Limited
• Johnson & Johnson Services Inc.
• TauRx Pharmaceuticals Ltd.
• Other Key Players

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