Withdrawn application: Susvimo, ranibizumab, Date of withdrawal: 02/05/2023, Initial authorisation
Susvimo was to be given via a refillable implant inserted into the eye. This implant was designed to release the medicine into the eye over time and to be refilled every 6 months by a doctor specialised in eye care.
The active substance in Susvimo, ranibizumab, is a small piece of a monoclonal antibody (a type of protein that has been designed to recognise and attach to a specific target called an antigen).
Ranibizumab attaches to and block a substance called vascular endothelial growth factor A (VEGF-A). VEGF-A is a protein that makes blood vessels grow and leak fluid and blood, damaging the macula. By blocking VEGF-A, ranibizumab reduces the growth of the blood vessels and controls the leakage and swelling.
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