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Tasrif Pharmaceutical Announces Grant of US Patent for Humanized Monoclonal Antibodies against the Poliovirus Receptor

USA, August 30, 2021 / -- Tasrif Pharmaceutical announces the grant of a US Patent related to its proprietary humanized monoclonal antibodies against the poliovirus receptor (a.k.a. CD155). The poliovirus receptor (PVR) is overexpressed on many malignancies including cancers of the brain, breast, colon and pancreas. Tasrif Pharmaceutical’s lead molecule, TSRF 786C is a potential best-in-class fully humanized IgG4 (S241P) monoclonal antibody against PVR.

Preclinical studies have shown that TSRF 786C has high affinity and specificity for PVR, low immunogenicity and a low risk of infusion reaction. TSRF 786C is currently being developed for the modulation of the DNAM 1-CD155-TIGIT Axis and blockade of the PVR-TIGIT checkpoint. Immunotherapeutics based on TSRF 786C, which include Bispecifics, ADCs, T-cell engagers and CAR-T cells, are in discovery. Tasrif Pharmaceutical’s humanized monoclonal antibodies against PVR have promise for targeted cancer immunotherapy. A US CIP and PCT are also pending.

About TSRF 786C
TSRF 786C is a fully humanized monoclonal antibody (IgG4 S241P) under preclinical development for the treatment of brain and systemic cancers that express PVR.

About Tasrif Pharmaceutical, LLC
Tasrif Pharmaceutical is a preclinical stage company that is a privately owned LLC incorporated in New York. Tasrif Pharmaceutical’s mission is to improve and prolong the lives of cancer patients.

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Tasrif Pharmaceutical, LLC