Dublin, July 05, 2019 (GLOBE NEWSWIRE) -- The "Zykadia" report has been added to ResearchAndMarkets.com's offering.

Zykadia (ceritinib; Novartis) is a tyrosine kinase inhibitor that targets anaplastic lymphoma kinase (ALK). In most ALK-positive non-small cell lung cancer (NSCLC) cases, inversions in chromosome 2 cause ALK to fuse to echinoderm microtubule-associated protein-like 4.

This activates the ALK kinase domain and downstream signaling pathways responsible for excess cancer cell proliferation. ALK gene rearrangements are found more commonly in younger, non-smoking NSCLC patients and make up 3-5% of all NSCLC cases.

Key Topics Covered

1. Drug Overview
2. Product Profiles
3. Zykadia : Non-small cell lung cancer (NSCLC)

LIST OF FIGURES
Figure 1: The authors drug assessment summary for Zykadia in non-small cell lung cancer
Figure 2: The authors drug assessment summary for ensartinib in non-small cell lung cancer

LIST OF TABLES
Table 1: Zykadia drug profile
Table 2: Zykadia pivotal trial data in non-small cell lung cancer
Table 3: Zykadia sales for NSCLC across the US, Japan, and five major EU markets, by country ($m), 2017-26
Table 4: Zykadia patient numbers for NSCLC across the US, Japan, and five major EU markets, by country, 2017-26

For more information about this report visit https://www.researchandmarkets.com/r/z0m2k5

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Related Topics: Lung Cancer Drugs