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Rostock researchers unravel heart failure mechanism in bone marrow stem cells

ROSTOCK, GERMANY, August 1, 2017 / -- The Rostock University cardiac surgeon, Prof. Gustav Steinhoff, and his research team, have now unraveled a cause of heart failure in bone marrow stem cells and published their results in EBioMedicine. In the phase 3 PERFECT-trial studying stem cell therapy in bypass patients, forty percent of all patients were identified as having a suppressed bone marrow response for repair related to the regulatory gene SH2B3. Insufficient bone marrow stem cells prevent small blood vessel growth in the heart muscle and by this cause progressive heart failure.

The researchers succeeded in finding a diagnostic biomarker signature in the peripheral blood of patients by using an artificial intelligence machine learning computer analysis system, allowing pretreatment identification of patient responders for improved heart function. Using this new computer-aided diagnostic technology, responsive patients can be accurately identified prior to treatment with bypass surgery and stem cells. For non-reactive patients, however, therapeutic approaches have to be intensively sought for.

Highlights of the study
1. Heart function improvement is dependent on circulating endothelial progenitor cells.
2. Suppression of bone marrow response is associated to SH2B3 gene expression
3. Peripheral blood angiogenesis response can be predicted by a biomarker signature

Media contact:
Dr. Ulrike Ruch, Reference and Translation Center for Cardiac Stem Cell Therapy, University Rostock;
Phone: +49-381 498 8974
Mobile:+49 179 39 39 344

PRESS RELEASE, August 1, 2017
Publication release:

Gustav Steinhoff, Prof. M.D.; Julia Nesteruk, M.D.; Markus
Wolfien; Guenther Kundt, Prof PhD; Jochen Boergermann, M.D.; Robert
David, Prof PhD; Jens Garbade, Prof MD; Jana grosse, Prof PhD; Axel
Haverich, Prof MD; Holger Hennig, PhD; Alexander Kaminski, M.D.; Joachim
Lotz, Prof MD; Friedrich W Mohr, Prof MD; Paula Mueller; Robert
Oostendorp, Prof PhD; Ulrike Ruch, PhD; Samir Sarikouch, Prof MD; Anna
Skorska, PhD; Christof Stamm, Prof MD; Gudrun Tiedemann, PhD; Florian M
Wagner, M.D.; Olaf Wolkenhauer, Prof PhD
Outcome analysis of the randomized PERFECT phase III clinical trial of intramyocardial CD133+ application after myocardial infarction

Prof. Dr. Gustav Steinhoff
University Medicine Rostock
+49 179 39 39 344
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