Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of …
Researchers from around 29 universities and institutions across North America have teamed up to create a large, versatile, and effective arsenal of new biological tools that will play a critical role in the battle against brain disease. The tools are known …
Cancers of the biliary tract system affect the network of ducts that connect the liver, gallbladder, and small intestine, and are aggressive, killing 9 out of 10 patients within just a few years of diagnosis. New research from the Broad Institute and …
A new direct-to-participant effort now underway is giving people the opportunity to participate in the largest and most diverse genetic study of anorexia nervosa and other eating disorders to date. Researchers at the Broad Institute Ben Neale and Mark Daly …
A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can …
Researchers from the Broad Institute and Columbia University have developed a way to insert entire healthy genes into human cells efficiently enough for potential therapeutic applications. It lays a foundation for gene-editing therapies for patients with …
Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The engineered protein, called NovaIscB, can be …
Growing up in the Sichuan province in China, Bo Xia was curious about the nature he saw around him: the creeks that ran through his hometown and its many animals and insects. In school, he loved imagining how molecules made up materials and whole organisms …
Since the earliest days of her scientific career, Melina Claussnitzer, a metabolic disease researcher at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease (NNFC) at the Broad Institute, has been thinking about how to accelerate the …
Diane Diehl excelled in math and science as a student, but in high school, she also got a taste for business. During summers, she worked at her father’s small engineering firm in Wheeling, Illinois, managing the office, handling payroll, and making sure …
Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset …
Gene editing pioneer David Liu, a core member at the Broad Institute where he is the Richard Merkin Professor and director of the Merkin Institute for Transformative Technologies in Healthcare, has been named a laureate of the 2025 Breakthrough Prize in …
When Maddie Murphy, a computational associate at the Broad Institute of MIT and Harvard, first learned she’d have the opportunity to pursue her research in Copenhagen, she envisioned a two- or three-week visit. Then her supervisor, Ray Jones, told her she …
In recent years, public discussions about autism, autism research, and individuals with autism have revealed a wide range of views, at times becoming contentious. Autism researchers at the Broad Institute of MIT and Harvard noticed that the discourse …
Count Me In, a patient-partnered research initiative led by the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, is launching a new project focused on translocation renal cell carcinoma (tRCC), a rare and aggressive form of kidney …
Two studies led by researchers at the Broad Institute of MIT and Harvard and Mass General Brigham have greatly expanded the number of known genetic variants that boost the risk for atrial fibrillation (AF), a common heart condition marked by irregular …
A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome editing toolbox. These systems, which the researchers call TIGR …
Immunotherapy has revolutionized the treatment of many cancers, but brain tumors such as gliomas remain particularly difficult to treat, in part because they potently suppress immune responses. New findings from researchers at the Broad Institute of MIT …
Broad Institute of MIT and Harvard has appointed Alex Rives, a leading computer scientist and pioneering artificial intelligence researcher, as a core institute member. Rives will also serve as an assistant professor in the Department of Electrical …
When Xiao Wang applied to faculty jobs, many of the institutions where she interviewed thought her research proposal — to study the life cycle of RNA in cells and how it influences normal development and disease — was too broad. However, that was not the …
