Tepkinly can only be obtained with a prescription and treatment must be started and supervised by a doctor experienced in treating cancer, in a location with appropriate medical support to manage severe side effects such as cytokine release syndrome (CRS, a potentially life-threatening condition that causes fever, vomiting, shortness of breath, headache and low blood pressure).

Tepkinly is given as an injection under the skin, in cycles of 28 days. Treatment starts with injections on days 1, 8 and 15 at increasing doses (so-called step-up dosing). After step-up dosing, patients are given the full dose on certain days of each cycle. Treatment can continue until the disease gets worse or the patient experiences unacceptable side effects.

Several medicines are given before Tepkinly to reduce the risk of CRS. Patients should also be closely monitored for serious side effects like CRS and immune effector cell-associated neurotoxicity syndrome (ICANS, a neurological disorder with symptoms including problems with speech and writing, confusion and depressed level of consciousness), especially after receiving the full dose for the first time.

For more information about using Tepkinly, see the package leaflet or contact your doctor or pharmacist.