Propulsion of Hepatitis B Virus Infection Clinical Trial Pipeline as Novel and Extensive 90+ Therapies Likely to Enter in the Treatment Domain | DelveInsight
The increased research and development activities for developing and launching new drugs are expected to fuel growth in the Hepatitis B Virus infection treatment market by providing an alternative treatment. The companies developing the potential therapies in the last stage of development include Xian Xintong Pharmaceutical Research, GlaxoSmithKline, PharmaEssentia, and others.
New York, USA, June 06, 2023 (GLOBE NEWSWIRE) -- Propulsion of Hepatitis B Virus Infection Clinical Trial Pipeline as Novel and Extensive 90+ Therapies Likely to Enter in the Treatment Domain | DelveInsight
The increased research and development activities for developing and launching new drugs are expected to fuel growth in the Hepatitis B Virus infection treatment market by providing an alternative treatment. The companies developing the potential therapies in the last stage of development include Xian Xintong Pharmaceutical Research, GlaxoSmithKline, PharmaEssentia, and others.
DelveInsight’s 'Hepatitis B Virus Infection Pipeline Insight 2023' report provides comprehensive global coverage of pipeline hepatitis B virus infection therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the hepatitis B virus infection pipeline domain.
Key Takeaways from the Hepatitis B Virus Infection Pipeline Report
- DelveInsight’s hepatitis B virus infection pipeline report depicts a robust space with 80+ active players working to develop 90+ pipeline therapies for hepatitis B virus infection treatment.
- Key hepatitis B virus infection companies such as Vir Biotechnology, Arbutus Biopharma, Nucorion Pharmaceuticals, Xian Xintong Pharmaceutical Research, Dong-A ST Co. Ltd., Gilead Sciences, Antios Therapeutics, Ascletis Pharmaceuticals, Shanghai HEP Pharmaceutical, Golden Biotechnology, Sunshine Lake Pharma, Ascentage Pharma, GlaxoSmithKline, Janssen Sciences, Tasly Tianjin Biopharmaceutical, Brii Biosciences, Zhejiang Palo Alto Pharmaceuticals, PharmaEssentia, Jiangsu HengRui Medicine, Enanta Pharmaceuticals, Chong Kun Dang Pharmaceutical, Guangzhou Lupeng Pharmaceutical, Zhimeng Biopharma, Dicerna Pharmaceuticals, Altimmune, Viravaxx, Aligos Therapeutics, GC Biopharma, Immunocore, Huahui Health, PRISM Pharma, Hepion Pharmaceuticals, Hepatera, Virion Therapeutics, HOOKIPA Pharma, OliX Pharmaceuticals, and others are evaluating new hepatitis B virus infection drugs to improve the treatment landscape.
- Promising hepatitis B virus infection pipeline therapies such as VIR 2218, AB 729, NCO-48, Pradefovir, DA 2802, Selgantolimod, ATI-2173, ASC42, Hepalatide, Antroquinonol, HEC121120, APG-1387, GSK3228836, JNJ-73763989, JNJ-56136379, T101, BRII-179, PA1010, P1101, HRS5091, EDP-514, CKD-388, LP-128, ZM-H1505R, ISA104, RG6346, HepTcell, VVX001, ALG-000184, GC5103, IMC-I109V, Myrcludex B, HH-003, CRV431, PRI-724, VRON-0200, HB-400, OLX703A, ALG-125755, and others are under different phases of hepatitis B virus infection clinical trials.
- In May 2023, HOOKIPA Pharma Inc. announced that the first person was dosed in a Gilead-led Phase 1 clinical trial of HB-400, an investigational therapeutic vaccine for chronic hepatitis B.
- In April 2023, Altimmune announced that it has completed enrollment in its Phase 2 clinical trial of HepTcell, an immunotherapeutic for the treatment of chronic hepatitis B (CHB). With the achievement of this milestone, data readout is planned for the first quarter of 2024.
- In February 2023, Center for Breakthrough Medicines (CBM) and Virion Therapeutics (Virion), a clinical-stage biotech company focused on the development of novel, adaptable, and accessible CD8+ T cell-based technologies focused on cancers and infectious diseases, announced a strategic collaboration agreement wherein CBM will manufacture and partner with Virion on their checkpoint modifier clinical development programs, including the First-in-Human VRON-0200 immunotherapy for patients with chronic Hepatitis B Virus (HBV) infection.
- In February 2023, VBI Vaccines announced interim data from the Phase 2 study evaluating the combination of VBI-2601 (BRII-179), VBI’s HBV immunotherapeutic candidate, and BRII-835 (VIR-2218), an HBV-targeting siRNA candidate, in chronically infected HBV patients.
- In January 2023, HOOKIPA Pharma Inc. announced that it had achieved a $5 million non-dilutive milestone payment under its collaboration agreement with Gilead Sciences. HOOKIPA completed and delivered a regulatory support package for Gilead’s Phase 1 clinical trial of an investigational therapeutic vaccine for chronic hepatitis B using HOOKIPA’s arenaviral platform.
- In July 2022, Brii Biosciences Limited announced that it exercised its option to acquire exclusive development and commercialization rights for VIR-3434 in Greater China as part of its broader collaboration with Vir Biotechnology, Inc. This move provides additional growth to the Company's leading clinical pipeline of therapeutic candidates for hepatitis B virus (HBV) and provides an expansive set of potential combination treatment options for Brii Bio to explore as part of its efforts to develop a functional cure for HBV.
Request a sample and discover the recent advances in hepatitis B virus infection treatment drugs @ Hepatitis B Virus Infection Pipeline Report
The hepatitis B virus infection pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage hepatitis B virus infection drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the hepatitis B virus infection clinical trial landscape.
Hepatitis B Virus Infection Overview
Hepatitis B is an infection of the liver caused by the hepatitis B virus. Some people with hepatitis B are only sick for a few weeks, but for others, the disease advances to chronic hepatitis B, which is a serious, lifelong sickness. Some people, particularly those who become infected as adults, are able to eliminate the virus from their bodies without the need for therapy. For others, acute hepatitis B progresses to chronic hepatitis B, a life-long infection. Chronic hepatitis B can lead to major health issues such as liver damage, cirrhosis, liver cancer, and even death. Age influences whether hepatitis B becomes chronic.
The common hepatitis B symptoms include fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, and others. Many persons with hepatitis B are unaware they are afflicted because they do not feel or appear unwell. They can, however, still spread the illness to others. The hepatitis B virus can live for at least 7 days outside the body. During that period, the virus can still cause infection. Getting vaccinated is the most effective strategy to avoid hepatitis B. Hepatitis B vaccination is both safe and effective.
Find out more about hepatitis B virus infection treatment drugs @ Drugs for Hepatitis B Virus Infection Treatment
A snapshot of the Hepatitis B Virus Infection Pipeline Drugs mentioned in the report:
| Drugs | Company | Phase | MoA | RoA |
| Pradefovir | Xian Xintong Pharmaceutical Research | Phase III | DNA-directed DNA polymerase inhibitors; Hepatitis B virus replication inhibitors | Oral |
| Bepirovirsen | GlaxoSmithKline | Phase III | Hepatitis B surface antigen expression inhibitor | Subcutaneous |
| VIR 2218 | Vir Biotechnology | Phase II | Hepatitis B surface antigen expression inhibitor | Subcutaneous |
| AB 729 | Arbutus Biopharma | Phase II | Hepatitis B surface antigen expression inhibitor; Hepatitis B virus replication inhibitor | Subcutaneous |
| Selgantolimod | Gilead Sciences | Phase II | Toll-like receptor 8 agonists | Oral |
| ASC42 | Ascletis | Phase II | Farnesoid X-activated receptor agonists; Hepatitis B surface antigen expression inhibitor | Oral |
| Hepalatide | Shanghai HEP Pharmaceutical | Phase II | Sodium-bile acid cotransporter modulators | Subcutaneous |
Learn more about the emerging hepatitis B virus infection pipeline therapies @ Hepatitis B Virus Infection Clinical Trials
Hepatitis B Virus Infection Therapeutics Assessment
The hepatitis B virus infection pipeline report proffers an integral view of the hepatitis B virus infection emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Hepatitis B Virus Infection Pipeline Report
- Coverage: Global
- Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
- Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
- Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Intravenous, Ophthalmic, Oral, Parenteral, Subcutaneous, Topical, Transdermal
- Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide, Small molecule
- Therapeutics Assessment By Mechanism of Action: Hepatitis B surface antigen expression inhibitors, Viral protein inhibitors, Hepatitis B virus replication inhibitors, DNA-directed DNA polymerase inhibitors, Nucleotide reverse transcriptase inhibitors, Toll-like receptor 8 agonists, Farnesoid X-activated receptor agonists, RNA inhibitors, Sodium-bile acid cotransporter modulators
- Key Hepatitis B Virus Infection Companies: Vir Biotechnology, Arbutus Biopharma, Nucorion Pharmaceuticals, Xian Xintong Pharmaceutical Research, Dong-A ST Co. Ltd., Gilead Sciences, Antios Therapeutics, Ascletis Pharmaceuticals, Shanghai HEP Pharmaceutical, Golden Biotechnology, Sunshine Lake Pharma, Ascentage Pharma, GlaxoSmithKline, Janssen Sciences, Tasly Tianjin Biopharmaceutical, Brii Biosciences, Zhejiang Palo Alto Pharmaceuticals, PharmaEssentia, Jiangsu HengRui Medicine, Enanta Pharmaceuticals, Chong Kun Dang Pharmaceutical, Guangzhou Lupeng Pharmaceutical, Zhimeng Biopharma, Dicerna Pharmaceuticals, Altimmune, Viravaxx, Aligos Therapeutics, GC Biopharma, Immunocore, Huahui Health, PRISM Pharma, Hepion Pharmaceuticals, Hepatera, Virion Therapeutics, HOOKIPA Pharma, OliX Pharmaceuticals, and others
- Key Hepatitis B Virus Infection Pipeline Therapies: VIR 2218, AB 729, NCO-48, Pradefovir, DA 2802, Selgantolimod, ATI-2173, ASC42, Hepalatide, Antroquinonol, HEC121120, APG-1387, GSK3228836, JNJ-73763989, JNJ-56136379, T101, BRII-179, PA1010, P1101, HRS5091, EDP-514, CKD-388, LP-128, ZM-H1505R, ISA104, RG6346, HepTcell, VVX001, ALG-000184, GC5103, IMC-I109V, Myrcludex B, HH-003, CRV431, PRI-724, VRON-0200, HB-400, OLX703A, ALG-125755, and others
Dive deep into rich insights for new drugs for hepatitis B virus infection treatment, visit @ Hepatitis B Virus Infection Drugs
Table of Contents
| 1. | Hepatitis B Virus Infection Pipeline Report Introduction |
| 2. | Hepatitis B Virus Infection Pipeline Report Executive Summary |
| 3. | Hepatitis B Virus Infection Pipeline: Overview |
| 4. | Analytical Perspective In-depth Commercial Assessment |
| 5. | Hepatitis B Virus Infection Clinical Trial Therapeutics |
| 6. | Hepatitis B Virus Infection Pipeline: Late-Stage Products (Pre-registration) |
| 7. | Hepatitis B Virus Infection Pipeline: Late-Stage Products (Phase III) |
| 8. | Hepatitis B Virus Infection Pipeline: Mid-Stage Products (Phase II) |
| 9. | Hepatitis B Virus Infection Pipeline: Early-Stage Products (Phase I) |
| 10. | Hepatitis B Virus Infection Pipeline Therapeutics Assessment |
| 11. | Inactive Products in the Hepatitis B Virus Infection Pipeline |
| 12. | Company-University Collaborations (Licensing/Partnering) Analysis |
| 13. | Key Companies |
| 14. | Key Products in the Hepatitis B Virus Infection Pipeline |
| 15. | Unmet Needs |
| 16. | Market Drivers and Barriers |
| 17. | Future Perspectives and Conclusion |
| 18. | Analyst Views |
| 19. | Appendix |
For further information on the hepatitis B virus infection pipeline therapeutics, reach out @ Hepatitis B Virus Infection Treatment Drugs
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